| pubmed-article:3495799 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3495799 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:3495799 | lifeskim:mentions | umls-concept:C0021758 | lld:lifeskim |
| pubmed-article:3495799 | lifeskim:mentions | umls-concept:C0814999 | lld:lifeskim |
| pubmed-article:3495799 | lifeskim:mentions | umls-concept:C1515126 | lld:lifeskim |
| pubmed-article:3495799 | lifeskim:mentions | umls-concept:C0018284 | lld:lifeskim |
| pubmed-article:3495799 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:3495799 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:3495799 | pubmed:dateCreated | 1987-7-8 | lld:pubmed |
| pubmed-article:3495799 | pubmed:abstractText | We have shown that recombinant or natural interleukin 4 (IL-4) (formerly called B-cell stimulatory factor 1) induces proliferation of activated adult or fetal thymocytes. In the case of adult thymocytes, IL-4 in combination with Con A or phorbol 12-myristate 13-acetate (PMA) stimulated the proliferation of peanut agglutinin (PNA)-negative (-) thymocytes, while PNA-positive (+) thymocytes showed only marginal responses. Further investigation revealed that day 14-17 fetal thymocytes, purified L3T4- LyT2- double-negative adult thymocytes, and single positive L3T4+ LyT2- or L3T4- LyT2+ thymocytes failed to respond to IL-4 or PMA alone but proliferated strongly with both IL-4 and PMA. In contrast, purified double-positive L3T4+ LyT2+ adult thymocytes showed only a marginal proliferative response to these stimuli. Responsiveness of thymic subpopulations to PMA and IL-4 could be inhibited with anti-IL-4 but not with anti-IL-2 monoclonal antibodies, indicating that they were IL-2 independent. Finally, we have observed that supernatants from calcium ionophore and PMA-stimulated adult double-negative L3T4- LyT2- thymocytes induce proliferation of double-negative adult thymocytes. This latter response is inhibited by anti-IL-4 monoclonal antibodies, suggesting that under appropriate stimulation conditions, these immature thymocytes are able to produce IL-4. These observations suggest a role for IL-4 in T-cell ontogeny. | lld:pubmed |
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| pubmed-article:3495799 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3495799 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3495799 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3495799 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3495799 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:3495799 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:3495799 | pubmed:author | pubmed-author:FischerMM | lld:pubmed |
| pubmed-article:3495799 | pubmed:author | pubmed-author:HowardMM | lld:pubmed |
| pubmed-article:3495799 | pubmed:author | pubmed-author:FrankGG | lld:pubmed |
| pubmed-article:3495799 | pubmed:author | pubmed-author:RansomJJ | lld:pubmed |
| pubmed-article:3495799 | pubmed:author | pubmed-author:ZlotnikAA | lld:pubmed |
| pubmed-article:3495799 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3495799 | pubmed:volume | 84 | lld:pubmed |
| pubmed-article:3495799 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3495799 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3495799 | pubmed:pagination | 3856-60 | lld:pubmed |
| pubmed-article:3495799 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:3495799 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3495799 | pubmed:articleTitle | Interleukin 4 is a growth factor for activated thymocytes: possible role in T-cell ontogeny. | lld:pubmed |
| pubmed-article:3495799 | pubmed:publicationType | Journal Article | lld:pubmed |
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