| pubmed-article:3492395 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3492395 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:3492395 | lifeskim:mentions | umls-concept:C1155065 | lld:lifeskim |
| pubmed-article:3492395 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:3492395 | pubmed:dateCreated | 1987-3-23 | lld:pubmed |
| pubmed-article:3492395 | pubmed:abstractText | The mutually exclusive expression of L3T4 and Lyt-2 on murine T cells and the correlation of their expression to the major histocompatibility complex (MHC) restriction of the T cell antigen receptor (Ti) have led to the hypothesis that these surface molecules are related to recognition of class II and class I MHC antigens, respectively. It has been suggested that these T cell surface molecules interact with nonpolymorphic determinants on MHC antigens. We have studied the role of L3T4 in activation of an H-2Dd-specific T cell hybridoma. This novel hybridoma allowed the separate evaluation of the specificities of Ti and L3T4 and the examination of their roles in T cell activation. Antibody-blocking experiments have demonstrated that L3T4 was involved in triggering this T cell hybridoma only if the antigen-bearing cell expressed Ia. The apparent requirement for an L3T4-Ia interaction reflected the amount of available H-2Dd antigen. It appears that the L3T4-Ia interaction influences T cell activation during suboptimal antigenic stimulation. We have begun to examine the role of L3T4 in lectin and anti-Ti monoclonal antibody stimulation of the same T cell hybridoma. These experiments have suggested a distinct role for L3T4 in the absence of Ia, as a mediator of a negative signal for activation. | lld:pubmed |
| pubmed-article:3492395 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3492395 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3492395 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3492395 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3492395 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3492395 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3492395 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3492395 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3492395 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3492395 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3492395 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:3492395 | pubmed:issn | 0014-9446 | lld:pubmed |
| pubmed-article:3492395 | pubmed:author | pubmed-author:BurakoffS JSJ | lld:pubmed |
| pubmed-article:3492395 | pubmed:author | pubmed-author:GreensteinJ... | lld:pubmed |
| pubmed-article:3492395 | pubmed:author | pubmed-author:SitkovskyM... | lld:pubmed |
| pubmed-article:3492395 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3492395 | pubmed:volume | 46 | lld:pubmed |
| pubmed-article:3492395 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3492395 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3492395 | pubmed:pagination | 313-6 | lld:pubmed |
| pubmed-article:3492395 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:3492395 | pubmed:meshHeading | pubmed-meshheading:3492395-... | lld:pubmed |
| pubmed-article:3492395 | pubmed:meshHeading | pubmed-meshheading:3492395-... | lld:pubmed |
| pubmed-article:3492395 | pubmed:meshHeading | pubmed-meshheading:3492395-... | lld:pubmed |
| pubmed-article:3492395 | pubmed:meshHeading | pubmed-meshheading:3492395-... | lld:pubmed |
| pubmed-article:3492395 | pubmed:meshHeading | pubmed-meshheading:3492395-... | lld:pubmed |
| pubmed-article:3492395 | pubmed:meshHeading | pubmed-meshheading:3492395-... | lld:pubmed |
| pubmed-article:3492395 | pubmed:meshHeading | pubmed-meshheading:3492395-... | lld:pubmed |
| pubmed-article:3492395 | pubmed:meshHeading | pubmed-meshheading:3492395-... | lld:pubmed |
| pubmed-article:3492395 | pubmed:meshHeading | pubmed-meshheading:3492395-... | lld:pubmed |
| pubmed-article:3492395 | pubmed:meshHeading | pubmed-meshheading:3492395-... | lld:pubmed |
| pubmed-article:3492395 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3492395 | pubmed:articleTitle | Distinct roles for L3T4 in T cell activation. | lld:pubmed |
| pubmed-article:3492395 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3492395 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3492395 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3492395 | lld:pubmed |
