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| pubmed-article:3489234 | lifeskim:mentions | umls-concept:C0598666 | lld:lifeskim |
| pubmed-article:3489234 | lifeskim:mentions | umls-concept:C0087049 | lld:lifeskim |
| pubmed-article:3489234 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:3489234 | lifeskim:mentions | umls-concept:C1880371 | lld:lifeskim |
| pubmed-article:3489234 | pubmed:issue | 17 | lld:pubmed |
| pubmed-article:3489234 | pubmed:dateCreated | 1986-10-3 | lld:pubmed |
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| pubmed-article:3489234 | pubmed:abstractText | The nucleotide sequences of 27 T-cell receptor beta cDNA clones isolated from a human peripheral lymphocyte library were determined and compared to five additional published sequences. These cDNA clones represent 22 distinct T-cell receptor beta-chain variable region (V beta) gene segment sequences, which fall into 15 different V beta gene subfamilies, each containing six or fewer members. From this analysis, we estimate that the repertoire of expressed human V beta genes is less than 59, apparently much smaller than the immunoglobulin heavy chain and light chain variable region (VH and VL) repertoires. Variability plots comparing these human V beta regions with each other and with published mouse V beta regions provide evidence for only four hypervariable regions homologous to those seen in comparisons of immunoglobulin V regions. Somatic hypermutation appears to be used infrequently, if at all, in these V beta genes. | lld:pubmed |
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| pubmed-article:3489234 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3489234 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3489234 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3489234 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3489234 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:3489234 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:3489234 | pubmed:author | pubmed-author:KunzEE | lld:pubmed |
| pubmed-article:3489234 | pubmed:author | pubmed-author:HoodLL | lld:pubmed |
| pubmed-article:3489234 | pubmed:author | pubmed-author:ConcannonPP | lld:pubmed |
| pubmed-article:3489234 | pubmed:author | pubmed-author:PickeringL... | lld:pubmed |
| pubmed-article:3489234 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3489234 | pubmed:volume | 83 | lld:pubmed |
| pubmed-article:3489234 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3489234 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3489234 | pubmed:pagination | 6598-602 | lld:pubmed |
| pubmed-article:3489234 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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