| pubmed-article:3488121 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3488121 | lifeskim:mentions | umls-concept:C0021755 | lld:lifeskim |
| pubmed-article:3488121 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:3488121 | lifeskim:mentions | umls-concept:C0449416 | lld:lifeskim |
| pubmed-article:3488121 | lifeskim:mentions | umls-concept:C1527200 | lld:lifeskim |
| pubmed-article:3488121 | lifeskim:mentions | umls-concept:C0302891 | lld:lifeskim |
| pubmed-article:3488121 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:3488121 | pubmed:dateCreated | 1986-9-17 | lld:pubmed |
| pubmed-article:3488121 | pubmed:abstractText | Several native and recombinant forms of human interleukin-1 (IL-1) and recombinant murine IL-1 were assayed for their ability to inhibit the growth of cell lines established from malignant and nonmalignant human sources. The amount of growth-inhibitory activity was compared to the units of half-maximal [3H]thymidine incorporation in mouse thymocyte cultures exposed to IL-1. Three malignant human mammary cell lines (MCF-7, T47D, and MDA-MB-415) were growth inhibited in the presence of both native and the alpha and beta forms of recombinant human IL-1. MDA-MB-415 was most sensitive. Although most sources of IL-1 showed good correlation between units of activity and percentage of growth inhibition, native IL-1 from Genzyme Corporation induced a cytotoxic effect. Murine IL-1 was less growth inhibitory than the human forms of the monokine. Human embryonic lung (HEL), adult fibroblast (CRL 1445), and transformed milk (HBL-100) lines were not growth inhibited when tested against any IL-1 source. A lung carcinoma (CALU-1) and a colon carcinoma (SW-48) were not inhibited by either the alpha or beta forms of human recombinant IL-1. | lld:pubmed |
| pubmed-article:3488121 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3488121 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3488121 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3488121 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3488121 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3488121 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3488121 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3488121 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3488121 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3488121 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3488121 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3488121 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:3488121 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:3488121 | pubmed:author | pubmed-author:TsaiS CSC | lld:pubmed |
| pubmed-article:3488121 | pubmed:author | pubmed-author:GaffneyE VEV | lld:pubmed |
| pubmed-article:3488121 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3488121 | pubmed:volume | 46 | lld:pubmed |
| pubmed-article:3488121 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3488121 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3488121 | pubmed:pagination | 3834-7 | lld:pubmed |
| pubmed-article:3488121 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:3488121 | pubmed:meshHeading | pubmed-meshheading:3488121-... | lld:pubmed |
| pubmed-article:3488121 | pubmed:meshHeading | pubmed-meshheading:3488121-... | lld:pubmed |
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| pubmed-article:3488121 | pubmed:meshHeading | pubmed-meshheading:3488121-... | lld:pubmed |
| pubmed-article:3488121 | pubmed:meshHeading | pubmed-meshheading:3488121-... | lld:pubmed |
| pubmed-article:3488121 | pubmed:meshHeading | pubmed-meshheading:3488121-... | lld:pubmed |
| pubmed-article:3488121 | pubmed:meshHeading | pubmed-meshheading:3488121-... | lld:pubmed |
| pubmed-article:3488121 | pubmed:meshHeading | pubmed-meshheading:3488121-... | lld:pubmed |
| pubmed-article:3488121 | pubmed:meshHeading | pubmed-meshheading:3488121-... | lld:pubmed |
| pubmed-article:3488121 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3488121 | pubmed:articleTitle | Lymphocyte-activating and growth-inhibitory activities for several sources of native and recombinant interleukin 1. | lld:pubmed |
| pubmed-article:3488121 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3488121 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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