| pubmed-article:3485697 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3485697 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:3485697 | lifeskim:mentions | umls-concept:C0039195 | lld:lifeskim |
| pubmed-article:3485697 | lifeskim:mentions | umls-concept:C0524637 | lld:lifeskim |
| pubmed-article:3485697 | lifeskim:mentions | umls-concept:C0063529 | lld:lifeskim |
| pubmed-article:3485697 | pubmed:dateCreated | 1986-5-5 | lld:pubmed |
| pubmed-article:3485697 | pubmed:abstractText | A recombinant vaccinia virus (NP-VAC) containing cDNA corresponding to segment 5, the nucleoprotein (NP) gene of influenza A/PR/8/34 virus was used to examine the specificity of human influenza virus immune cytotoxic T lymphocytes (CTL). Effector cell preparations from two donors recognized autologous lymphocytes that had been infected with NP-VAC. Lysis was specific because cells infected with vaccinia virus were not killed and recognition was HLA-restricted. In one donor, the influenza virus-specific CTL response changed with time so that his effector cells no longer recognized autologous lymphocytes infected with NP-VAC. However, a component that was NP-specific remained because these CTL lysed the more sensitive autologous B lymphoblastoid cells that had been infected with NP-VAC. In four other donors, no NP-specific CTL response could be detected using autologous lymphocyte targets. Thus NP, an internal virus protein, is one antigen that is recognized by human influenza A virus-specific CTL, but it is likely that other individual virus components contribute to the total CTL response. | lld:pubmed |
| pubmed-article:3485697 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3485697 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3485697 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3485697 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:3485697 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3485697 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3485697 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:3485697 | pubmed:issn | 0022-1317 | lld:pubmed |
| pubmed-article:3485697 | pubmed:author | pubmed-author:McMichaelA... | lld:pubmed |
| pubmed-article:3485697 | pubmed:author | pubmed-author:SmithG LGL | lld:pubmed |
| pubmed-article:3485697 | pubmed:author | pubmed-author:MossBB | lld:pubmed |
| pubmed-article:3485697 | pubmed:author | pubmed-author:GotchF MFM | lld:pubmed |
| pubmed-article:3485697 | pubmed:author | pubmed-author:MichieC ACA | lld:pubmed |
| pubmed-article:3485697 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3485697 | pubmed:volume | 67 ( Pt 4) | lld:pubmed |
| pubmed-article:3485697 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3485697 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3485697 | pubmed:pagination | 719-26 | lld:pubmed |
| pubmed-article:3485697 | pubmed:dateRevised | 2006-11-20 | lld:pubmed |
| pubmed-article:3485697 | pubmed:meshHeading | pubmed-meshheading:3485697-... | lld:pubmed |
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| pubmed-article:3485697 | pubmed:meshHeading | pubmed-meshheading:3485697-... | lld:pubmed |
| pubmed-article:3485697 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3485697 | pubmed:articleTitle | Recognition of influenza A virus nucleoprotein by human cytotoxic T lymphocytes. | lld:pubmed |
| pubmed-article:3485697 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3485697 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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