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pubmed-article:3480534pubmed:abstractTextWe have cloned genomic DNA encoding a non-HLA-A, -B, -C class I gene located within a HindIII-generated restriction fragment of 6.0 kilobase pairs. This gene, designated HLA-6.0, is as homologous to HLA-A and HLA-B as they are to each other. The HLA class I protein encoded by HLA-6.0 is similar in organization to the HLA-A-, -B-, and -C-encoded proteins except that an in-frame termination codon prevents translation of a majority of the cytoplasmic region of the HLA-6.0 polypeptide. Moreover, the promoter region of HLA-6.0 resembles the promoter region of a Qa region gene. These structural features of HLA-6.0 suggest that this non-HLA-A, -B, -C gene is a structural homolog of a murine Qa region class I gene.lld:pubmed
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pubmed-article:3480534pubmed:articleTitleA human major histocompatibility complex class I gene that encodes a protein with a shortened cytoplasmic segment.lld:pubmed
pubmed-article:3480534pubmed:affiliationInstitute of Human Genetics, University of Minnesota, Minneapolis 55455.lld:pubmed
pubmed-article:3480534pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:3480534pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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