| pubmed-article:3460172 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3460172 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:3460172 | lifeskim:mentions | umls-concept:C0031327 | lld:lifeskim |
| pubmed-article:3460172 | lifeskim:mentions | umls-concept:C0025519 | lld:lifeskim |
| pubmed-article:3460172 | lifeskim:mentions | umls-concept:C0028978 | lld:lifeskim |
| pubmed-article:3460172 | pubmed:dateCreated | 1986-7-25 | lld:pubmed |
| pubmed-article:3460172 | pubmed:abstractText | Four studies of the pharmacokinetics and metabolism of omeprazole are briefly discussed. Two of these were carried out in young healthy subjects and indicated that about 54% of an oral dose is available to the systemic circulation. The distribution of omeprazole after an intravenous dose was consistent with localization of a major fraction of the drug in the extracellular water, with about 25% restricted to the blood. Omeprazole was rapidly cleared and possessed the characteristics of a high clearance drug; insignificant amounts of 14C-omeprazole were excreted by the kidneys, though metabolites were excreted very rapidly. Six different metabolites were reported, the major one being hydroxy-omeprazole. Increasing the intravenous dose of omeprazole from 10 mg to 40 mg had no significant effect on the pharmacokinetic parameters determined. A study in patients with impaired renal function showed that this had little effect on the kinetics of omeprazole, though excretion of metabolites was significantly affected. A study of elderly healthy subjects suggested that the disposition characteristics of omeprazole are affected to some extent by age; further studies are needed to elucidate the clinical implications. Omeprazole has been reported to prolong the half-life of diazepam which may be due to inhibition of the demethylation of diazepam. The interaction of omeprazole with the kinetics of aminopyrine and antipyrine was much less pronounced. | lld:pubmed |
| pubmed-article:3460172 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3460172 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3460172 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3460172 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3460172 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3460172 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3460172 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3460172 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3460172 | pubmed:issn | 0085-5928 | lld:pubmed |
| pubmed-article:3460172 | pubmed:author | pubmed-author:RegårdhC GCG | lld:pubmed |
| pubmed-article:3460172 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3460172 | pubmed:volume | 118 | lld:pubmed |
| pubmed-article:3460172 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3460172 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3460172 | pubmed:pagination | 99-104 | lld:pubmed |
| pubmed-article:3460172 | pubmed:dateRevised | 2008-2-13 | lld:pubmed |
| pubmed-article:3460172 | pubmed:meshHeading | pubmed-meshheading:3460172-... | lld:pubmed |
| pubmed-article:3460172 | pubmed:meshHeading | pubmed-meshheading:3460172-... | lld:pubmed |
| pubmed-article:3460172 | pubmed:meshHeading | pubmed-meshheading:3460172-... | lld:pubmed |
| pubmed-article:3460172 | pubmed:meshHeading | pubmed-meshheading:3460172-... | lld:pubmed |
| pubmed-article:3460172 | pubmed:meshHeading | pubmed-meshheading:3460172-... | lld:pubmed |
| pubmed-article:3460172 | pubmed:meshHeading | pubmed-meshheading:3460172-... | lld:pubmed |
| pubmed-article:3460172 | pubmed:meshHeading | pubmed-meshheading:3460172-... | lld:pubmed |
| pubmed-article:3460172 | pubmed:meshHeading | pubmed-meshheading:3460172-... | lld:pubmed |
| pubmed-article:3460172 | pubmed:meshHeading | pubmed-meshheading:3460172-... | lld:pubmed |
| pubmed-article:3460172 | pubmed:meshHeading | pubmed-meshheading:3460172-... | lld:pubmed |
| pubmed-article:3460172 | pubmed:meshHeading | pubmed-meshheading:3460172-... | lld:pubmed |
| pubmed-article:3460172 | pubmed:meshHeading | pubmed-meshheading:3460172-... | lld:pubmed |
| pubmed-article:3460172 | pubmed:meshHeading | pubmed-meshheading:3460172-... | lld:pubmed |
| pubmed-article:3460172 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3460172 | pubmed:articleTitle | Pharmacokinetics and metabolism of omeprazole in man. | lld:pubmed |
| pubmed-article:3460172 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3460172 | lld:pubmed |
