| pubmed-article:3456593 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3456593 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:3456593 | lifeskim:mentions | umls-concept:C0017258 | lld:lifeskim |
| pubmed-article:3456593 | lifeskim:mentions | umls-concept:C1516511 | lld:lifeskim |
| pubmed-article:3456593 | lifeskim:mentions | umls-concept:C0005221 | lld:lifeskim |
| pubmed-article:3456593 | lifeskim:mentions | umls-concept:C0205360 | lld:lifeskim |
| pubmed-article:3456593 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:3456593 | pubmed:dateCreated | 1986-4-10 | lld:pubmed |
| pubmed-article:3456593 | pubmed:abstractText | The DNase I-hypersensitive sites in the human embryonic beta-globin gene region have been mapped in erythroid-enriched fractions of disaggregated fetal livers, in adult nucleated red blood cells, and in fetal brain tissue. Our analysis of a region extending 11 kilobases (kb) 5' of the epsilon-globin gene reveals many minor nuclease-hypersensitive sites and one major site located 6.1 kb upstream of the epsilon-globin gene. All of these hypersensitive sites are erythroid-specific, and the major site is stable throughout erythroid development. As assayed by nuclear runoff transcription, little or no epsilon-globin gene expression is detectable in fetal or adult erythroid cells. Thus, the presence of the major hypersensitive site 5' of the epsilon-globin gene in both fetal and adult erythroid cells demonstrates that this site is not specifically correlated with transcription of the gene or with a particular stage of development. Rather, this site may reflect an early event in erythroid differentiation. In addition, DNase I has been used to probe the overall sensitivity of epsilon-globin chromatin in fetal erythroid cells. Our findings indicate that the epsilon-globin gene as well as the other genes in the beta-globin cluster reside within the chromatin domain that is more DNase I-sensitive than "bulk" chromatin. | lld:pubmed |
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| pubmed-article:3456593 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3456593 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3456593 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3456593 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3456593 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:3456593 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:3456593 | pubmed:author | pubmed-author:GroudineMM | lld:pubmed |
| pubmed-article:3456593 | pubmed:author | pubmed-author:ThompsonCC | lld:pubmed |
| pubmed-article:3456593 | pubmed:author | pubmed-author:ElderJ TJT | lld:pubmed |
| pubmed-article:3456593 | pubmed:author | pubmed-author:ForresterW... | lld:pubmed |
| pubmed-article:3456593 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3456593 | pubmed:volume | 83 | lld:pubmed |
| pubmed-article:3456593 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3456593 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3456593 | pubmed:pagination | 1359-63 | lld:pubmed |
| pubmed-article:3456593 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:3456593 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3456593 | pubmed:articleTitle | A developmentally stable chromatin structure in the human beta-globin gene cluster. | lld:pubmed |
| pubmed-article:3456593 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3456593 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3456593 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:3456593 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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