| pubmed-article:34548 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:34548 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:34548 | lifeskim:mentions | umls-concept:C0036394 | lld:lifeskim |
| pubmed-article:34548 | lifeskim:mentions | umls-concept:C0028351 | lld:lifeskim |
| pubmed-article:34548 | lifeskim:mentions | umls-concept:C0004462 | lld:lifeskim |
| pubmed-article:34548 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:34548 | pubmed:dateCreated | 1979-6-26 | lld:pubmed |
| pubmed-article:34548 | pubmed:abstractText | The intraaxonal transport of noradrenaline and tyrosine hydroxylase was studied in the sciatic nerves of diabetic, obese and appropriate control mice. Noradrenaline and tyrosine hydroxylase accumulated proximal to a constriction applied to the nerves. Noradrenaline concentration in the non-constricted sciatic nerves did not differ significantly in nondiabetic and diabetic mice (0.67 +/- 0.04 and 0.58 +/- 0.01 ng/cm respectively); in obese mice and lean littermates the noradrenaline concentration was 0.47 +/- 0.05 ng/cm and 0.46 +/- 0.01 ng/cm. After nine hours of constriction the concentration of noradrenaline increased in the axons of nondiabetic (1.15 +/- 0.06 ng/cm), in obese (0.90 +/- 0.08 ng/cm) and lean mice (1.10 +/- 0.07 ng/cm) but remained low (0.68 +/- 0.07 ng/cm) in diabetic mice.--Administration of insulin (10 U/kg/day) to diabetic mutants completely reversed the decrease in NA accumulation. NA accumulated only in the nerve segment proximal (1 cm) to a constriction and was transported distally at an apparent velocity of 0.75 mm/hr in control axons. The difference of NA accumulation between diabetic and nondiabetic control indicate a reduced rate of axoplasmic flow in the noradrenergic axons of diabetic animals. | lld:pubmed |
| pubmed-article:34548 | pubmed:language | eng | lld:pubmed |
| pubmed-article:34548 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:34548 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:34548 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:34548 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:34548 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:34548 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:34548 | pubmed:issn | 0012-186X | lld:pubmed |
| pubmed-article:34548 | pubmed:author | pubmed-author:GiachettiAA | lld:pubmed |
| pubmed-article:34548 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:34548 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:34548 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:34548 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:34548 | pubmed:pagination | 191-4 | lld:pubmed |
| pubmed-article:34548 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:34548 | pubmed:meshHeading | pubmed-meshheading:34548-An... | lld:pubmed |
| pubmed-article:34548 | pubmed:meshHeading | pubmed-meshheading:34548-Mi... | lld:pubmed |
| pubmed-article:34548 | pubmed:meshHeading | pubmed-meshheading:34548-Di... | lld:pubmed |
| pubmed-article:34548 | pubmed:meshHeading | pubmed-meshheading:34548-Sc... | lld:pubmed |
| pubmed-article:34548 | pubmed:meshHeading | pubmed-meshheading:34548-Ma... | lld:pubmed |
| pubmed-article:34548 | pubmed:meshHeading | pubmed-meshheading:34548-No... | lld:pubmed |
| pubmed-article:34548 | pubmed:meshHeading | pubmed-meshheading:34548-Ax... | lld:pubmed |
| pubmed-article:34548 | pubmed:meshHeading | pubmed-meshheading:34548-Ty... | lld:pubmed |
| pubmed-article:34548 | pubmed:meshHeading | pubmed-meshheading:34548-Mi... | lld:pubmed |
| pubmed-article:34548 | pubmed:year | 1979 | lld:pubmed |
| pubmed-article:34548 | pubmed:articleTitle | Axoplasmic transport of noradrenaline in the sciatic nerves of spontaneously diabetic mice. | lld:pubmed |
| pubmed-article:34548 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:34548 | lld:pubmed |
