Linked Life Data

3446809

Source:http://linkedlifedata.com/resource/pubmed/id/3446809

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pubmed-article:3446809pubmed:abstractText1. The effects of variations in pH between 7.00 and 6.20 on Ca2+ -activated tension development and maximum velocity of shortening (Vmax) were examined in skinned single skeletal fibres from rat slow-twitch soleus and fast-twitch superficial (s.v.l.) and deep (d.v.l.) regions of the vastus lateralis muscle. 2. At pH 6.50, Vmax was depressed to a similar degree in each of the soleus, d.v.l., and s.v.l. fibres. Lowering pH to 6.20 resulted in a further decline in Vmax in all fibres; however, differences between the slow fibres, identified by SDS-polyacrylamide gel electrophoresis, and fast fibres were apparent, with soleus retaining a significantly greater proportion of its control Vmax (0.83 +/- 0.03 in soleus vs. 0.69 +/- 0.03 in s.v.l.; mean +/- S.E.M.). 3. Maximum force production decreased significantly as pH was reduced. Peak force at pH 6.50, relative to that at pH 7.00, was significantly greater in soleus (0.80 +/- 0.01) than in the s.v.l. (0.75 +/- 0.01) fibres. At pH 6.20 these differences between slow and fast fibres were still greater, in that soleus fibres generated significantly greater relative forces (0.73 +/- 0.01) than did d.v.l. (0.67 +/- 0.02) or s.v.l. (0.63 +/- 0.02) fibres. 4. As pH was lowered the tension-pCa relationship shifted to the right (i.e. to higher [Ca2+]), indicating a reduction in the Ca2+ sensitivity of tension development. The [Ca2+] necessary to achieve half-maximal tension in both the slow- and fast-twitch fibres increased approximately 5-fold when pH was lowered from 7.00 to 6.20. Furthermore, in the case of the soleus, the Ca2+ threshold for tension development was 45 times greater at pH 6.20 than at pH 7.00, while in the fast-twitch fibres, this increase was 4-fold. 5. Increased [H+] differentially affected the steepness of the tension-pCa relationship between slow and fast fibres. As pH was lowered, the steepness of the lower portion of the tension-pCa curve increased in the soleus and decreased in d.v.l. and s.v.l., suggesting that apparent positive co-operativity of tension development had increased in soleus and decreased in d.v.l. and s.v.l. fibres. 6. These results (1) demonstrate an increased resistance to H+ ion-mediated contractile dysfunction in slow- compared to fast-twitch single fibres, and (2) support the hypothesis that muscular fatigue resulting from short-term, intense muscular contraction may in part be related to elevated H+ ion concentration.lld:pubmed
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pubmed-article:3446809pubmed:authorpubmed-author:MossR LRLlld:pubmed
pubmed-article:3446809pubmed:authorpubmed-author:MetzgerJ MJMlld:pubmed
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pubmed-article:3446809pubmed:dateRevised2009-11-18lld:pubmed
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pubmed-article:3446809pubmed:articleTitleGreater hydrogen ion-induced depression of tension and velocity in skinned single fibres of rat fast than slow muscles.lld:pubmed
pubmed-article:3446809pubmed:affiliationDepartment of Physiology, School of Medicine, University of Wisconsin, Madison 53706.lld:pubmed
pubmed-article:3446809pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:3446809pubmed:publicationTypeIn Vitrolld:pubmed
pubmed-article:3446809pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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