| pubmed-article:3440960 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3440960 | lifeskim:mentions | umls-concept:C0241888 | lld:lifeskim |
| pubmed-article:3440960 | lifeskim:mentions | umls-concept:C1269683 | lld:lifeskim |
| pubmed-article:3440960 | lifeskim:mentions | umls-concept:C1521797 | lld:lifeskim |
| pubmed-article:3440960 | lifeskim:mentions | umls-concept:C0205225 | lld:lifeskim |
| pubmed-article:3440960 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:3440960 | pubmed:dateCreated | 1988-4-8 | lld:pubmed |
| pubmed-article:3440960 | pubmed:abstractText | This is a study of the familial transmission of Primary Major Depressive Disorder in the families of 235 probands with this disorder ascertained as part of the NIMH-CRB Collaborative Depression Program. Eight hundred and twenty-six interviewed first degree relatives and 109 spouses are included. Research Diagnostic Criteria have been used and interviews were done using the SADS-L schedule. Prior analyses of these data have established the presence of strong secular trends in the age-of-onset and prevalence of Major Depressive Disorder in these families. Accordingly, new methods for the analysis of family data which incorporate secular variation were developed. Non-parametric Survival Analysis, using the Cox Proportional Hazards Model, guided the formulation of a quantitative family transmission model. Then a family analysis was conducted with the Multifactorial Model of Disease Transmission and the Tau Path Analytic Model. Using the non-parametric approach, only the sibs birth cohort, sex and affectational status of the mother were significantly related to the time of onset of illness in siblings. Proband sex, age-of-onset, and the presence of illness in the father were not significant. The quantitative analysis confirmed that more recently born cohorts of individuals had an increased expected lifetime prevalence and a decreased age-of-onset of Primary Major Depressive Disorder. Assortative mating was present and environmental factors common to siblings did not make a significant contribution to the phenotypic variance. Sex specific transmissibilities were found and the transmissibility in females (t2 = 0.62) was significantly greater than that of males (t2 = 0.28). There was a trend for the transmissibility of Primary Major Disorder to be greater in more recently born cohorts. | lld:pubmed |
| pubmed-article:3440960 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3440960 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3440960 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3440960 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3440960 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3440960 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3440960 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3440960 | pubmed:issn | 0022-3956 | lld:pubmed |
| pubmed-article:3440960 | pubmed:author | pubmed-author:RiceJJ | lld:pubmed |
| pubmed-article:3440960 | pubmed:author | pubmed-author:KlermanG LGL | lld:pubmed |
| pubmed-article:3440960 | pubmed:author | pubmed-author:ReichTT | lld:pubmed |
| pubmed-article:3440960 | pubmed:author | pubmed-author:MullaneyJJ | lld:pubmed |
| pubmed-article:3440960 | pubmed:author | pubmed-author:EndicottJJ | lld:pubmed |
| pubmed-article:3440960 | pubmed:author | pubmed-author:Van... | lld:pubmed |
| pubmed-article:3440960 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3440960 | pubmed:volume | 21 | lld:pubmed |
| pubmed-article:3440960 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3440960 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3440960 | pubmed:pagination | 613-24 | lld:pubmed |
| pubmed-article:3440960 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:3440960 | pubmed:meshHeading | pubmed-meshheading:3440960-... | lld:pubmed |
| pubmed-article:3440960 | pubmed:meshHeading | pubmed-meshheading:3440960-... | lld:pubmed |
| pubmed-article:3440960 | pubmed:meshHeading | pubmed-meshheading:3440960-... | lld:pubmed |
| pubmed-article:3440960 | pubmed:meshHeading | pubmed-meshheading:3440960-... | lld:pubmed |
| pubmed-article:3440960 | pubmed:meshHeading | pubmed-meshheading:3440960-... | lld:pubmed |
| pubmed-article:3440960 | pubmed:meshHeading | pubmed-meshheading:3440960-... | lld:pubmed |
| pubmed-article:3440960 | pubmed:meshHeading | pubmed-meshheading:3440960-... | lld:pubmed |
| pubmed-article:3440960 | pubmed:meshHeading | pubmed-meshheading:3440960-... | lld:pubmed |
| pubmed-article:3440960 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3440960 | pubmed:articleTitle | The familial transmission of primary major depressive disorder. | lld:pubmed |
| pubmed-article:3440960 | pubmed:affiliation | Department of Psychiatry, Washington University, St. Louis, Missouri. | lld:pubmed |
| pubmed-article:3440960 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3440960 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3440960 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3440960 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3440960 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3440960 | lld:pubmed |
