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pubmed-article:3438167pubmed:abstractTextMyocardial time-activity curves can be described by two or more parameters. To establish the optimal curve fitting method 33 myocardial time-activity curves were analyzed with different curve fitting methods: monoexponential, biexponential and monoexponential plus constant. A background correction was not applied. Biexponential curve fitting resulted in redundancy of parameters. Optimal curve fitting was obtained with monoexponential plus constant. The constant represents the background activity together with the stored radiolabelled lipids and the half-time value represents the wash-out of radioiodide from the myocardium. A strong relation was found between the constant and the half-time value: small errors in the determination of the constant (background activity) resulted in considerable errors of the half-time value. It is concluded that optimal analysis of a myocardial time-activity curve can be performed with a monoexponential plus constant without earlier correction for background activity.lld:pubmed
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pubmed-article:3438167pubmed:authorpubmed-author:WesteraGGlld:pubmed
pubmed-article:3438167pubmed:authorpubmed-author:BezemerP DPDlld:pubmed
pubmed-article:3438167pubmed:authorpubmed-author:RoosJ PJPlld:pubmed
pubmed-article:3438167pubmed:authorpubmed-author:VisserF CFClld:pubmed
pubmed-article:3438167pubmed:authorpubmed-author:Van EenigeM...lld:pubmed
pubmed-article:3438167pubmed:authorpubmed-author:KarremanA JAJlld:pubmed
pubmed-article:3438167pubmed:authorpubmed-author:DuwelC MCMlld:pubmed
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pubmed-article:3438167pubmed:volume26lld:pubmed
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pubmed-article:3438167pubmed:pagination241-7lld:pubmed
pubmed-article:3438167pubmed:dateRevised2007-1-12lld:pubmed
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pubmed-article:3438167pubmed:year1987lld:pubmed
pubmed-article:3438167pubmed:articleTitleAnalysis of myocardial time-activity curves of 123I-heptadecanoic acid. I. Curve fitting.lld:pubmed
pubmed-article:3438167pubmed:affiliationDepartment of Cardiology, Free University, Amsterdam, The Netherlands.lld:pubmed
pubmed-article:3438167pubmed:publicationTypeJournal Articlelld:pubmed