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pubmed-article:3412896pubmed:dateCreated1988-10-5lld:pubmed
pubmed-article:3412896pubmed:abstractTextThe reagent obtained in situ by treating methylphosphonothioic dichloride with 1-hydroxy-6-trifluoromethylbenzotriazole could be used for the introduction of methylphosphonothioate linkages. The individual diastereomers of the protected dimer d-Tp(S,Me)A were applied in the synthesis of the chiral pure (R or S) hexamers d-[CpCpTp(S,Me)ApGpG]. The reagent showed also to be very effective for the preparation of the 3',5'-cyclic methylphosphonothioate of uridine.lld:pubmed
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pubmed-article:3412896pubmed:authorpubmed-author:van BoomJ HJHlld:pubmed
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pubmed-article:3412896pubmed:authorpubmed-author:RoelenH CHClld:pubmed
pubmed-article:3412896pubmed:authorpubmed-author:de VroomEElld:pubmed
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pubmed-article:3412896pubmed:pagination7633-45lld:pubmed
pubmed-article:3412896pubmed:dateRevised2009-11-18lld:pubmed
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pubmed-article:3412896pubmed:year1988lld:pubmed
pubmed-article:3412896pubmed:articleTitleSynthesis of nucleic acid methylphosphonothioates.lld:pubmed
pubmed-article:3412896pubmed:affiliationGorlaeus Laboratory, Leiden, The Netherlands.lld:pubmed
pubmed-article:3412896pubmed:publicationTypeJournal Articlelld:pubmed