Source:http://linkedlifedata.com/resource/pubmed/id/3411455
General Info
Affiliation
Department of Medicinal Chemistry, University of Mississippi, University 38677.Abstract
When racemic primaquine was administered to rats, the majority of the residual primaquine excreted in urine was found to be the (+)-isomer. Using a liver microsome preparation, there was no selectivity in the metabolism of the (+)- and (-)-isomers; however, a liver fraction containing mitochondria and microsomes did show selectivity. In the latter preparation, there was a marked preference for the conversion of (-)-primaquine to (-)-carboxy-primaquine.
PMID
3411455
Publication types
Comparative Study; In Vitro; Research Support, Non-U.S. Gov't