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pubmed-article:3402402pubmed:abstractTextSubstantial responses in the 6-week and mature body-weights of mice occurred after 7 generations of selection for or against plasma levels of Insulin-like Growth Factor-1 (IGF-1). Plasma levels of IGF-1 were also significantly different after 7 generations of selection (high line = 85 +/- 2 ng/ml, low line = 58 +/- 2 ng/ml). The average 6-week weight in the line selected for high plasma IGF-1 was 22.5 +/- .2 g compared with 18.5 +/- .2 g in the low plasma IGF-1 line, after 7 generations of selection. The difference between lines was maintained at 20 weeks of age. These data provide further evidence for the roles of IGF-1 in the regulation of somatic growth and as a mediator of a genetic component of growth.lld:pubmed
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pubmed-article:3402402pubmed:authorpubmed-author:GluckmanP DPDlld:pubmed
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pubmed-article:3402402pubmed:dateRevised2009-11-19lld:pubmed
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pubmed-article:3402402pubmed:year1988lld:pubmed
pubmed-article:3402402pubmed:articleTitleGenetic selection for insulin-like growth factor-1 in growing mice is associated with altered growth.lld:pubmed
pubmed-article:3402402pubmed:affiliationDepartment of Animal Science, Massey University, Palmerston North, New Zealand.lld:pubmed
pubmed-article:3402402pubmed:publicationTypeJournal Articlelld:pubmed
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pubmed-article:3402402pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed