| pubmed-article:3401713 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3401713 | lifeskim:mentions | umls-concept:C1511649 | lld:lifeskim |
| pubmed-article:3401713 | lifeskim:mentions | umls-concept:C1521751 | lld:lifeskim |
| pubmed-article:3401713 | lifeskim:mentions | umls-concept:C0006104 | lld:lifeskim |
| pubmed-article:3401713 | lifeskim:mentions | umls-concept:C0032005 | lld:lifeskim |
| pubmed-article:3401713 | lifeskim:mentions | umls-concept:C0234194 | lld:lifeskim |
| pubmed-article:3401713 | lifeskim:mentions | umls-concept:C0728831 | lld:lifeskim |
| pubmed-article:3401713 | lifeskim:mentions | umls-concept:C0597879 | lld:lifeskim |
| pubmed-article:3401713 | lifeskim:mentions | umls-concept:C0205146 | lld:lifeskim |
| pubmed-article:3401713 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:3401713 | lifeskim:mentions | umls-concept:C0443172 | lld:lifeskim |
| pubmed-article:3401713 | lifeskim:mentions | umls-concept:C2699782 | lld:lifeskim |
| pubmed-article:3401713 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:3401713 | pubmed:dateCreated | 1988-9-15 | lld:pubmed |
| pubmed-article:3401713 | pubmed:abstractText | The present study characterizes the time course of social conflict analgesia and its reversibility by opioid antagonist drugs in the C57BL/6 and DBA/2 inbred strains of mice and examines the relationship between alterations in brain and pituitary levels of beta-endorphin-like immunoreactivity (beta-ELIR) and the antinociception elicited by social stress. Data revealed statistically significant strain differences in regard to beta-ELIR in control animals. The pituitary content of beta-ELIR was higher in DBA/2, while the values in the periaqueductal grey (PAG) and in the amygdala were higher in C57BL/6 mice. No interstrain differences were found in the hypothalamus. Exposure to 50 attack bites resulted in a 6-fold higher analgesia in DBA/2 mice and in a strain-independent fall of beta-ELIR in pituitary (approximately 27%) and PAG (23%). PAG but not pituitary beta-ELIR levels in C57BL/6 mice correlated positively with the increase in tail-flick latency after attack. Mere confrontation with a non-aggressive opponent failed to induce analgesia and was associated in C57BL/6 mice with a significant reduction in the beta-ELIR content of both the pituitary and the PAG. The data are discussed in terms of genotype-dependent sensitivity of the beta-endorphin system to stress and its relation to analgesia. | lld:pubmed |
| pubmed-article:3401713 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3401713 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3401713 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3401713 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3401713 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3401713 | pubmed:month | May | lld:pubmed |
| pubmed-article:3401713 | pubmed:issn | 0006-8993 | lld:pubmed |
| pubmed-article:3401713 | pubmed:author | pubmed-author:WaserP GPG | lld:pubmed |
| pubmed-article:3401713 | pubmed:author | pubmed-author:PasiAA | lld:pubmed |
| pubmed-article:3401713 | pubmed:author | pubmed-author:SiegfriedBB | lld:pubmed |
| pubmed-article:3401713 | pubmed:author | pubmed-author:FrischknechtH... | lld:pubmed |
| pubmed-article:3401713 | pubmed:author | pubmed-author:PalliniRR | lld:pubmed |
| pubmed-article:3401713 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3401713 | pubmed:day | 31 | lld:pubmed |
| pubmed-article:3401713 | pubmed:volume | 450 | lld:pubmed |
| pubmed-article:3401713 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3401713 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3401713 | pubmed:pagination | 237-46 | lld:pubmed |
| pubmed-article:3401713 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:3401713 | pubmed:meshHeading | pubmed-meshheading:3401713-... | lld:pubmed |
| pubmed-article:3401713 | pubmed:meshHeading | pubmed-meshheading:3401713-... | lld:pubmed |
| pubmed-article:3401713 | pubmed:meshHeading | pubmed-meshheading:3401713-... | lld:pubmed |
| pubmed-article:3401713 | pubmed:meshHeading | pubmed-meshheading:3401713-... | lld:pubmed |
| pubmed-article:3401713 | pubmed:meshHeading | pubmed-meshheading:3401713-... | lld:pubmed |
| pubmed-article:3401713 | pubmed:meshHeading | pubmed-meshheading:3401713-... | lld:pubmed |
| pubmed-article:3401713 | pubmed:meshHeading | pubmed-meshheading:3401713-... | lld:pubmed |
| pubmed-article:3401713 | pubmed:meshHeading | pubmed-meshheading:3401713-... | lld:pubmed |
| pubmed-article:3401713 | pubmed:meshHeading | pubmed-meshheading:3401713-... | lld:pubmed |
| pubmed-article:3401713 | pubmed:meshHeading | pubmed-meshheading:3401713-... | lld:pubmed |
| pubmed-article:3401713 | pubmed:meshHeading | pubmed-meshheading:3401713-... | lld:pubmed |
| pubmed-article:3401713 | pubmed:meshHeading | pubmed-meshheading:3401713-... | lld:pubmed |
| pubmed-article:3401713 | pubmed:meshHeading | pubmed-meshheading:3401713-... | lld:pubmed |
| pubmed-article:3401713 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:3401713 | pubmed:articleTitle | Social conflict-induced changes in nociception and beta-endorphin-like immunoreactivity in pituitary and discrete brain areas of C57BL/6 and DBA/2 mice. | lld:pubmed |
| pubmed-article:3401713 | pubmed:affiliation | Institute of Pharmacology, University of Zurich, Switzerland. | lld:pubmed |
| pubmed-article:3401713 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3401713 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:3401713 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3401713 | lld:pubmed |
