| pubmed-article:3396627 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3396627 | lifeskim:mentions | umls-concept:C0002502 | lld:lifeskim |
| pubmed-article:3396627 | lifeskim:mentions | umls-concept:C0039629 | lld:lifeskim |
| pubmed-article:3396627 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:3396627 | lifeskim:mentions | umls-concept:C1167622 | lld:lifeskim |
| pubmed-article:3396627 | lifeskim:mentions | umls-concept:C0220795 | lld:lifeskim |
| pubmed-article:3396627 | lifeskim:mentions | umls-concept:C0243071 | lld:lifeskim |
| pubmed-article:3396627 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:3396627 | pubmed:dateCreated | 1988-8-31 | lld:pubmed |
| pubmed-article:3396627 | pubmed:abstractText | The ability of amiloride and its analogues to inhibit [3H]batrachotoxinin-A 20-alpha benzoate [( 3H]BTX-B) and [3H]tetracaine binding to rat synaptosomes and to a rat heart membrane preparation was tested. Their ability to inhibit 22Na influx was determined with rat synaptosomes. 5-N-substituted analogues were generally more potent in inhibiting [3H]BTX-B and [3H]tetracaine binding than compounds substituted on the guanidine group. However, the inhibition was not competitive. Amiloride and some of its analogues were as active or more active in inhibiting [3H]tetracaine binding than they were in inhibiting [3H]BTX-B binding. 22Na influx was inhibited with the same relative potencies as [3H]BTX-B binding and a good correlation was found between the two inhibitions. These results show an effect of amiloride and its analogues on the voltage-sensitive Na+ channels, which could partly explain the inotropic effects of these drugs. | lld:pubmed |
| pubmed-article:3396627 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3396627 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3396627 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3396627 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3396627 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:3396627 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3396627 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3396627 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3396627 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3396627 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:3396627 | pubmed:issn | 0014-2999 | lld:pubmed |
| pubmed-article:3396627 | pubmed:author | pubmed-author:SchwartzJJ | lld:pubmed |
| pubmed-article:3396627 | pubmed:author | pubmed-author:VellyJJ | lld:pubmed |
| pubmed-article:3396627 | pubmed:author | pubmed-author:DeckerNN | lld:pubmed |
| pubmed-article:3396627 | pubmed:author | pubmed-author:CragoeE JEJJr | lld:pubmed |
| pubmed-article:3396627 | pubmed:author | pubmed-author:GrimmAA | lld:pubmed |
| pubmed-article:3396627 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3396627 | pubmed:day | 27 | lld:pubmed |
| pubmed-article:3396627 | pubmed:volume | 149 | lld:pubmed |
| pubmed-article:3396627 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3396627 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3396627 | pubmed:pagination | 97-105 | lld:pubmed |
| pubmed-article:3396627 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:3396627 | pubmed:meshHeading | pubmed-meshheading:3396627-... | lld:pubmed |
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| pubmed-article:3396627 | pubmed:meshHeading | pubmed-meshheading:3396627-... | lld:pubmed |
| pubmed-article:3396627 | pubmed:meshHeading | pubmed-meshheading:3396627-... | lld:pubmed |
| pubmed-article:3396627 | pubmed:meshHeading | pubmed-meshheading:3396627-... | lld:pubmed |
| pubmed-article:3396627 | pubmed:meshHeading | pubmed-meshheading:3396627-... | lld:pubmed |
| pubmed-article:3396627 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:3396627 | pubmed:articleTitle | Effects of amiloride and its analogues on [3H]batrachotoxinin-A 20-alpha benzoate binding, [3H]tetracaine binding and 22Na influx. | lld:pubmed |
| pubmed-article:3396627 | pubmed:affiliation | Institut de Pharmacologie (UA 589 CNRS) Faculté de Médecine, Strasbourg, France. | lld:pubmed |
| pubmed-article:3396627 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3396627 | pubmed:publicationType | In Vitro | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3396627 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3396627 | lld:pubmed |
