| pubmed-article:3391280 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3391280 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:3391280 | lifeskim:mentions | umls-concept:C0022634 | lld:lifeskim |
| pubmed-article:3391280 | lifeskim:mentions | umls-concept:C0042285 | lld:lifeskim |
| pubmed-article:3391280 | lifeskim:mentions | umls-concept:C0064833 | lld:lifeskim |
| pubmed-article:3391280 | lifeskim:mentions | umls-concept:C0444626 | lld:lifeskim |
| pubmed-article:3391280 | lifeskim:mentions | umls-concept:C1999216 | lld:lifeskim |
| pubmed-article:3391280 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:3391280 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:3391280 | pubmed:dateCreated | 1988-8-18 | lld:pubmed |
| pubmed-article:3391280 | pubmed:abstractText | The stoichiometric complex formed between human leukocyte elastase and a synthetic MeO-Suc-Ala-Ala-Pro-Val chloromethyl ketone inhibitor was co-crystallized and its X-ray structure determined, using Patterson search methods. Its structure has been crystallographically refined to a final R value of 0.145 (8.0 and 2.3 A). The enzyme structure is very similar to that recently observed in a complex formed with the ovomucoid third domain from turkey [(1986) EMBO J. 5,2453-2458]. The rms deviation of all alpha-carbon atoms is 0.32 A. The peptidic inhibitor is bound in a similar overall conformation as the ovomucoid binding segment. Covalent bonds are formed between Val-P1 of the inhibitor and His-57 NE2 and Ser-195 OG of the enzyme. The carbonyl carbon is tetrahedrally deformed to a hemiketal. The valine side chain is arranged in the S1 pocket in the g-conformation. | lld:pubmed |
| pubmed-article:3391280 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3391280 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3391280 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3391280 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3391280 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3391280 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3391280 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3391280 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:3391280 | pubmed:issn | 0014-5793 | lld:pubmed |
| pubmed-article:3391280 | pubmed:author | pubmed-author:BodeWW | lld:pubmed |
| pubmed-article:3391280 | pubmed:author | pubmed-author:MayrII | lld:pubmed |
| pubmed-article:3391280 | pubmed:author | pubmed-author:WeiA ZAZ | lld:pubmed |
| pubmed-article:3391280 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3391280 | pubmed:day | 18 | lld:pubmed |
| pubmed-article:3391280 | pubmed:volume | 234 | lld:pubmed |
| pubmed-article:3391280 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3391280 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3391280 | pubmed:pagination | 367-73 | lld:pubmed |
| pubmed-article:3391280 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:3391280 | pubmed:meshHeading | pubmed-meshheading:3391280-... | lld:pubmed |
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| pubmed-article:3391280 | pubmed:meshHeading | pubmed-meshheading:3391280-... | lld:pubmed |
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| pubmed-article:3391280 | pubmed:meshHeading | pubmed-meshheading:3391280-... | lld:pubmed |
| pubmed-article:3391280 | pubmed:meshHeading | pubmed-meshheading:3391280-... | lld:pubmed |
| pubmed-article:3391280 | pubmed:meshHeading | pubmed-meshheading:3391280-... | lld:pubmed |
| pubmed-article:3391280 | pubmed:meshHeading | pubmed-meshheading:3391280-... | lld:pubmed |
| pubmed-article:3391280 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:3391280 | pubmed:articleTitle | The refined 2.3 A crystal structure of human leukocyte elastase in a complex with a valine chloromethyl ketone inhibitor. | lld:pubmed |
| pubmed-article:3391280 | pubmed:affiliation | Max-Planck-Institut für Biochemie, Martinsried, FRG. | lld:pubmed |
| pubmed-article:3391280 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3391280 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:1991 | entrezgene:pubmed | pubmed-article:3391280 | lld:entrezgene |
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