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pubmed-article:3348898pubmed:abstractTextRadiation sensitivity was determined for nine University of Michigan squamous cell carcinoma (UM-SCC) cell lines, MCF-7 and HeLa, using a 96-well plate clonogenic assay. Plating efficiencies (PE) of the UM-SCC cell lines were between 0.16 and 0.36. Higher PE values obtained were with MCF-7 (0.4) and HeLa (0.5). The UM-SCC cell lines were used at low passages (passage 13 to passage 20) to minimize artifacts attributable to long-term culture. Cells were irradiated in suspension using a cobalt 60 gamma source at a dose rate of 0.94 Gy/min (94 rad/min). Survival data were fitted well by either a linear quadratic function F = e-(alpha D + beta D2) or by a monoexponential function F = Ae-alpha D. Mean inactivation dose, equivalent to the area under the survival curve (AUC), was used as a measure of radiation sensitivity. The UM-SCC-1, 9, 11A, 11B, MCF-7, and HeLa were the most radiation resistant lines we tested (AUC greater than 2.1), while UM-SCC-14A was the most sensitive (AUC = 1.591). The assay was highly reproducible, and the difference in radiation sensitivity between cell lines were statistically significant.lld:pubmed
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pubmed-article:3348898pubmed:authorpubmed-author:VirolainenEElld:pubmed
pubmed-article:3348898pubmed:authorpubmed-author:WagnerJ GJGlld:pubmed
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pubmed-article:3348898pubmed:volume114lld:pubmed
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pubmed-article:3348898pubmed:pagination427-31lld:pubmed
pubmed-article:3348898pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:3348898pubmed:year1988lld:pubmed
pubmed-article:3348898pubmed:articleTitleRadiosensitivity of head and neck cancer cells in vitro. A 96-well plate clonogenic cell assay for squamous cell carcinoma.lld:pubmed
pubmed-article:3348898pubmed:affiliationLoimaa Finland Regional Hospital.lld:pubmed
pubmed-article:3348898pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:3348898pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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