| pubmed-article:3340203 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3340203 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:3340203 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:3340203 | lifeskim:mentions | umls-concept:C1709634 | lld:lifeskim |
| pubmed-article:3340203 | pubmed:issue | 6156 | lld:pubmed |
| pubmed-article:3340203 | pubmed:dateCreated | 1988-3-17 | lld:pubmed |
| pubmed-article:3340203 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3340203 | pubmed:abstractText | Insulin and related peptides are key hormonal integrators of growth and metabolism in vertebrates. There is little biochemical evidence for insulin-related peptides in invertebrates, apart from insects for which definitive structural information on these peptides (prothoracicotropic hormone, PTTH) has recently been obtained. We report here the first complete complementary DNA-derived primary structure of a preproinsulin-related protein from identified neurons in an invertebrate, the mollusc Lymnaea stagnalis. We have demonstrated by in situ hybridization that transcription of the gene for this molluscan insulin-related peptide (MIP) occurs in the cerebral light-green cells, giant neuroendocrine cells involved in the control of growth, as well as in a pair of neuroendocrine cells called the canopy cells. The insulin-related peptide precursor has the same overall structure as its vertebrate counterparts. The discovery of insulin-related peptides in invertebrates substantiates the evidence for a widespread and early evolutionary origin of the insulin superfamily. | lld:pubmed |
| pubmed-article:3340203 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3340203 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3340203 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3340203 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:3340203 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3340203 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3340203 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:3340203 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:3340203 | pubmed:author | pubmed-author:EbberinkR HRH | lld:pubmed |
| pubmed-article:3340203 | pubmed:author | pubmed-author:KlootwijkJJ | lld:pubmed |
| pubmed-article:3340203 | pubmed:author | pubmed-author:GeraertsW PWP | lld:pubmed |
| pubmed-article:3340203 | pubmed:author | pubmed-author:JoosseJJ | lld:pubmed |
| pubmed-article:3340203 | pubmed:author | pubmed-author:SmitA BAB | lld:pubmed |
| pubmed-article:3340203 | pubmed:author | pubmed-author:VreugdenhilEE | lld:pubmed |
| pubmed-article:3340203 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3340203 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:3340203 | pubmed:volume | 331 | lld:pubmed |
| pubmed-article:3340203 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3340203 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3340203 | pubmed:pagination | 535-8 | lld:pubmed |
| pubmed-article:3340203 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:3340203 | pubmed:meshHeading | pubmed-meshheading:3340203-... | lld:pubmed |
| pubmed-article:3340203 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:3340203 | pubmed:articleTitle | Growth-controlling molluscan neurons produce the precursor of an insulin-related peptide. | lld:pubmed |
| pubmed-article:3340203 | pubmed:affiliation | Biologisch Laboratorium, Vrije Universiteit, Amsterdam, The Netherlands. | lld:pubmed |
| pubmed-article:3340203 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3340203 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:3340203 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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