| pubmed-article:3337226 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3337226 | lifeskim:mentions | umls-concept:C0034493 | lld:lifeskim |
| pubmed-article:3337226 | lifeskim:mentions | umls-concept:C0042149 | lld:lifeskim |
| pubmed-article:3337226 | lifeskim:mentions | umls-concept:C0470187 | lld:lifeskim |
| pubmed-article:3337226 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:3337226 | lifeskim:mentions | umls-concept:C0301818 | lld:lifeskim |
| pubmed-article:3337226 | pubmed:issue | 1 Pt 1 | lld:pubmed |
| pubmed-article:3337226 | pubmed:dateCreated | 1988-2-23 | lld:pubmed |
| pubmed-article:3337226 | pubmed:abstractText | The metabolic clearance rate (MCR) of gonadal or adrenal steroid hormones in rabbits often does not bear the expected inverse relationship with hormone binding to testosterone-binding globulin (TeBG) or corticosteroid-binding globulin (CBG). This suggests TeBG or CBG may not impede steroid hormone delivery to tissues. The effects of rabbit plasma proteins on the influxes of 3H-labeled steroids from the circulation into the rabbit uterus were measured in vivo using a tissue sampling single-injection technique. In the absence of plasma proteins, estradiol (E2) and testosterone (T) were freely diffusible through the uterine microvasculature (i.e., extraction greater than 80%). The extractions of dihydrotestosterone (DHT) and corticosterone (B) ranged from 60 to 72%, while that of cortisol (F) was reduced at 40%. Rabbit serum exerted no inhibition of the influxes of the steroids tested. The influxes of T and B greatly exceeded the rates that would be expected if only the free and albumin-bound fractions estimated in vitro were diffusible in vivo. However, the extraction of [3H]corticosteroid-binding globulin or bovine [3H]albumin were low, consistent with little, if any, extravascular uptake of the plasma proteins. The results indicate both albumin-bound and globulin-bound steroid hormone are available for transport into the uterus in the rabbit in vivo without significant exodus of the plasma protein, per se. | lld:pubmed |
| pubmed-article:3337226 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3337226 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3337226 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3337226 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3337226 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3337226 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3337226 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3337226 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3337226 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3337226 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3337226 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3337226 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3337226 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3337226 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3337226 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3337226 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:3337226 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:3337226 | pubmed:author | pubmed-author:ChaudhuriGG | lld:pubmed |
| pubmed-article:3337226 | pubmed:author | pubmed-author:PardridgeW... | lld:pubmed |
| pubmed-article:3337226 | pubmed:author | pubmed-author:JuddH LHL | lld:pubmed |
| pubmed-article:3337226 | pubmed:author | pubmed-author:SteingoldK... | lld:pubmed |
| pubmed-article:3337226 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3337226 | pubmed:volume | 254 | lld:pubmed |
| pubmed-article:3337226 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3337226 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3337226 | pubmed:pagination | E79-83 | lld:pubmed |
| pubmed-article:3337226 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:3337226 | pubmed:meshHeading | pubmed-meshheading:3337226-... | lld:pubmed |
| pubmed-article:3337226 | pubmed:meshHeading | pubmed-meshheading:3337226-... | lld:pubmed |
| pubmed-article:3337226 | pubmed:meshHeading | pubmed-meshheading:3337226-... | lld:pubmed |
| pubmed-article:3337226 | pubmed:meshHeading | pubmed-meshheading:3337226-... | lld:pubmed |
| pubmed-article:3337226 | pubmed:meshHeading | pubmed-meshheading:3337226-... | lld:pubmed |
| pubmed-article:3337226 | pubmed:meshHeading | pubmed-meshheading:3337226-... | lld:pubmed |
| pubmed-article:3337226 | pubmed:meshHeading | pubmed-meshheading:3337226-... | lld:pubmed |
| pubmed-article:3337226 | pubmed:meshHeading | pubmed-meshheading:3337226-... | lld:pubmed |
| pubmed-article:3337226 | pubmed:meshHeading | pubmed-meshheading:3337226-... | lld:pubmed |
| pubmed-article:3337226 | pubmed:meshHeading | pubmed-meshheading:3337226-... | lld:pubmed |
| pubmed-article:3337226 | pubmed:meshHeading | pubmed-meshheading:3337226-... | lld:pubmed |
| pubmed-article:3337226 | pubmed:meshHeading | pubmed-meshheading:3337226-... | lld:pubmed |
| pubmed-article:3337226 | pubmed:meshHeading | pubmed-meshheading:3337226-... | lld:pubmed |
| pubmed-article:3337226 | pubmed:meshHeading | pubmed-meshheading:3337226-... | lld:pubmed |
| pubmed-article:3337226 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:3337226 | pubmed:articleTitle | TeBG- and CBG-bound steroid hormones in rabbits are available for influx into uterus in vivo. | lld:pubmed |
| pubmed-article:3337226 | pubmed:affiliation | Department of Obstetrics and Gynecology, School of Medicine, University of California, Los Angeles 90024. | lld:pubmed |
| pubmed-article:3337226 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3337226 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
