| pubmed-article:3336353 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3336353 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:3336353 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:3336353 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:3336353 | lifeskim:mentions | umls-concept:C1514566 | lld:lifeskim |
| pubmed-article:3336353 | lifeskim:mentions | umls-concept:C0086149 | lld:lifeskim |
| pubmed-article:3336353 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:3336353 | pubmed:dateCreated | 1988-2-10 | lld:pubmed |
| pubmed-article:3336353 | pubmed:abstractText | Several genes which are deactivated on the initiation of development of Dictyostelium discoideum were identified by differential screening of various cDNA libraries. These genes have in common a decrease in the steady-state levels of their corresponding mRNAs on the onset of development and as development proceeds. When development was carried out in the absence of protein synthesis by inhibition with cycloheximide, the decrease in mRNA levels for most genes (V genes) was normal or slightly accelerated. For about 5% of the genes (H genes), however, cycloheximide caused an apparent induction of expression, as revealed by a slight or dramatic increase in mRNA levels, instead of the normal decrease. This effect was due to inhibition of protein synthesis and not to cycloheximide per se. The induction was found to be due to an enhancement of the transcription rate; normal rates of transcription for the H genes were dependent on continued protein synthesis during vegetative growth and development. Thus, two general regulatory classes exist for deactivation of gene expression on initiation of development, one of which is dependent on and one of which is independent of protein synthesis. Analysis of expression of these genes in mutant strains which are aggregation deficient allowed the classes to be subdivided further. Taken together, these characterizations allow several distinct regulatory mechanisms to be identified that are involved in the deactivation of gene expression on the onset of development in D. discoideum. | lld:pubmed |
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| pubmed-article:3336353 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:3336353 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3336353 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3336353 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:3336353 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:3336353 | pubmed:author | pubmed-author:FengYY | lld:pubmed |
| pubmed-article:3336353 | pubmed:author | pubmed-author:SingletonC... | lld:pubmed |
| pubmed-article:3336353 | pubmed:author | pubmed-author:ManningS SSS | lld:pubmed |
| pubmed-article:3336353 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3336353 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:3336353 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3336353 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3336353 | pubmed:pagination | 10-6 | lld:pubmed |
| pubmed-article:3336353 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:3336353 | pubmed:meshHeading | pubmed-meshheading:3336353-... | lld:pubmed |
| pubmed-article:3336353 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:3336353 | pubmed:articleTitle | Effect of protein synthesis inhibition on gene expression during early development of Dictyostelium discoideum. | lld:pubmed |
| pubmed-article:3336353 | pubmed:affiliation | Department of Molecular Biology, Vanderbilt University, Nashville, Tennessee 37235. | lld:pubmed |
| pubmed-article:3336353 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3336353 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:3336353 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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