| pubmed-article:3325734 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3325734 | lifeskim:mentions | umls-concept:C0038477 | lld:lifeskim |
| pubmed-article:3325734 | lifeskim:mentions | umls-concept:C0243072 | lld:lifeskim |
| pubmed-article:3325734 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:3325734 | pubmed:dateCreated | 1988-4-7 | lld:pubmed |
| pubmed-article:3325734 | pubmed:abstractText | A series of K-region, N-substituted phenanthrene imines were tested for mutagenicity in Salmonella typhimurium TA100. All chemicals were mutagenic in the absence of an exogenous metabolic activation system. The apparent decay times of the mutagenic species in diffusion plates and their alkylating activities were also measured. The unsubstituted phenanthrene-9,10-imine was approximately 70-fold more mutagenic than the corresponding phenanthrene-9,10-oxide. N-substitution with electron-releasing groups resulted in chemicals that were more mutagenic than those substituted with electron-withdrawing groups. The mutagenic activity of the latter group of chemicals was comparable with that of phenanthrene-9,10-oxide. Except for N-chlorophenanthrene imine, both alkylation of p-nitrothiophenol and apparent decay times in diffusion plates were inversely correlated with mutagenicity. It is hypothesized that reactivity towards p-nitrothiophenol (alkylating activity) and mutagenicity reflect different reactions, in contrast to other chemical mutagens. The results suggest that the high potency of phenanthrene imines as mutagens is possibly due to DNA binding via an aziridinium ion rather than a carbonium ion. | lld:pubmed |
| pubmed-article:3325734 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3325734 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3325734 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3325734 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3325734 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3325734 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3325734 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3325734 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3325734 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3325734 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3325734 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:3325734 | pubmed:issn | 0267-8357 | lld:pubmed |
| pubmed-article:3325734 | pubmed:author | pubmed-author:LifshitzYY | lld:pubmed |
| pubmed-article:3325734 | pubmed:author | pubmed-author:BlumJJ | lld:pubmed |
| pubmed-article:3325734 | pubmed:author | pubmed-author:ZeigerEE | lld:pubmed |
| pubmed-article:3325734 | pubmed:author | pubmed-author:StarkA AAA | lld:pubmed |
| pubmed-article:3325734 | pubmed:author | pubmed-author:ShtelzerSS | lld:pubmed |
| pubmed-article:3325734 | pubmed:author | pubmed-author:SheradskyTT | lld:pubmed |
| pubmed-article:3325734 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3325734 | pubmed:volume | 1 | lld:pubmed |
| pubmed-article:3325734 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3325734 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3325734 | pubmed:pagination | 35-9 | lld:pubmed |
| pubmed-article:3325734 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:3325734 | pubmed:meshHeading | pubmed-meshheading:3325734-... | lld:pubmed |
| pubmed-article:3325734 | pubmed:meshHeading | pubmed-meshheading:3325734-... | lld:pubmed |
| pubmed-article:3325734 | pubmed:meshHeading | pubmed-meshheading:3325734-... | lld:pubmed |
| pubmed-article:3325734 | pubmed:meshHeading | pubmed-meshheading:3325734-... | lld:pubmed |
| pubmed-article:3325734 | pubmed:meshHeading | pubmed-meshheading:3325734-... | lld:pubmed |
| pubmed-article:3325734 | pubmed:meshHeading | pubmed-meshheading:3325734-... | lld:pubmed |
| pubmed-article:3325734 | pubmed:meshHeading | pubmed-meshheading:3325734-... | lld:pubmed |
| pubmed-article:3325734 | pubmed:meshHeading | pubmed-meshheading:3325734-... | lld:pubmed |
| pubmed-article:3325734 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3325734 | pubmed:articleTitle | Structure-activity relationships in the mutagenicity of N-substituted derivatives of phenanthrene-9,10-imine. | lld:pubmed |
| pubmed-article:3325734 | pubmed:affiliation | Department of Biochemistry, Tel Aviv University, Ramat Aviv, Israel. | lld:pubmed |
| pubmed-article:3325734 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3325734 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3325734 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
