| pubmed-article:3316037 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3316037 | lifeskim:mentions | umls-concept:C0005715 | lld:lifeskim |
| pubmed-article:3316037 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:3316037 | lifeskim:mentions | umls-concept:C0162388 | lld:lifeskim |
| pubmed-article:3316037 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:3316037 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:3316037 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:3316037 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:3316037 | pubmed:dateCreated | 1988-1-6 | lld:pubmed |
| pubmed-article:3316037 | pubmed:abstractText | The mechanism(s) by which lymphokine-activated peritoneal macrophages kill Blastomyces dermatitidis was studied. Resident peritoneal macrophages from BALB/cByJ mice, when treated overnight with lymph node cells plus concanavalin A, supernatants from concanavalin A-stimulated spleen cells, or recombinant gamma interferon, were then able to kill a virulent B. dermatitidis isolate (ATCC 26199) (at levels of 25% +/- 4%, 28% +/- 8%, and 21% +/- 5%, respectively). Killing was not significantly decreased or enhanced in the presence of superoxide dismutase (450 U/ml), catalase (20,000 U/ml), dimethyl sulfoxide (300 mM), or azide (1 mM). Viable B. dermatitidis elicited a brisk oxidative burst and superoxide anion production in activated macrophages as measured by lucigenin-enhanced chemiluminescence, e.g., 10(4) cpm. However, these responses were not significantly different from those of control macrophages. Luminol-enhanced chemiluminescence responses by activated or control macrophages were meager (less than or equal to 10(2) cpm). These results indicate that activated macrophages kill B. dermatitidis by a mechanism(s) independent of products of the oxidative burst. | lld:pubmed |
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| pubmed-article:3316037 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3316037 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3316037 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3316037 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3316037 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:3316037 | pubmed:issn | 0019-9567 | lld:pubmed |
| pubmed-article:3316037 | pubmed:author | pubmed-author:StevensD ADA | lld:pubmed |
| pubmed-article:3316037 | pubmed:author | pubmed-author:BrummerEE | lld:pubmed |
| pubmed-article:3316037 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3316037 | pubmed:volume | 55 | lld:pubmed |
| pubmed-article:3316037 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3316037 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3316037 | pubmed:pagination | 3221-4 | lld:pubmed |
| pubmed-article:3316037 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:3316037 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3316037 | pubmed:articleTitle | Fungicidal mechanisms of activated macrophages: evidence for nonoxidative mechanisms for killing of Blastomyces dermatitidis. | lld:pubmed |
| pubmed-article:3316037 | pubmed:affiliation | Department of Medicine, Santa Clara Valley Medical Center, San Jose, California. | lld:pubmed |
| pubmed-article:3316037 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3316037 | pubmed:publicationType | In Vitro | lld:pubmed |
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