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| pubmed-article:32943 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
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| pubmed-article:32943 | lifeskim:mentions | umls-concept:C0999699 | lld:lifeskim |
| pubmed-article:32943 | lifeskim:mentions | umls-concept:C0018787 | lld:lifeskim |
| pubmed-article:32943 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
| pubmed-article:32943 | lifeskim:mentions | umls-concept:C0019588 | lld:lifeskim |
| pubmed-article:32943 | lifeskim:mentions | umls-concept:C0680727 | lld:lifeskim |
| pubmed-article:32943 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:32943 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:32943 | lifeskim:mentions | umls-concept:C1563350 | lld:lifeskim |
| pubmed-article:32943 | lifeskim:mentions | umls-concept:C1511938 | lld:lifeskim |
| pubmed-article:32943 | lifeskim:mentions | umls-concept:C1563351 | lld:lifeskim |
| pubmed-article:32943 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:32943 | pubmed:dateCreated | 1979-4-25 | lld:pubmed |
| pubmed-article:32943 | pubmed:abstractText | 1 Differentiation of the roles of histamine H1- and H2-receptors in the mediation of the effects of histamine on the isolated working heart of the guinea-pig was achieved through the use of histamine and selective histamine receptor agonists and antagonists. 2 Histamine over the dose range 10(-9) mol to 10(-6) mol produced dose-related increases in sinus rate, left intraventricular pressure (LVP)max, LVdP/dtmax, coronary flow, aortic flow, total cardiac output and external pressure-volume work. 3 Dimaprit, a selective histamine H2-receptor agonist, produced very similar responses to histamine. 4 2-Pyridylethylamine, a selective histamine H1-receptor agonist, had little effect on cardiac function unless large doses were administered. Such doses produced increases in all measured parameters. 5 Cimetidine, a selective histamine H2-receptor antagonist, antagonized the effects of histamine and dimaprit and some but not all effects of 2-pyridylethylamine. In the presence of cimetidine a decrease in all parameters with the exception of sinus rate was observed with both histamine and 2-pyridylethylamine. 6 The selective histamine H1-receptor antagonist, mepyramine, had little effect on responses to all three agonists. However, the depressant effects observed with histamine and 2-pyridylethylamine in the presence of cimetidine were antagonized by mepyramine. 7 The results indicate the important role of the histamine H2-receptor in the mediation of the gross cardiac effects of histamine and also indicate that histamine H1-receptors can mediate cardiac depression. | lld:pubmed |
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| pubmed-article:32943 | pubmed:language | eng | lld:pubmed |
| pubmed-article:32943 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:32943 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:32943 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:32943 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:32943 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:32943 | pubmed:issn | 0007-1188 | lld:pubmed |
| pubmed-article:32943 | pubmed:author | pubmed-author:OwenD ADA | lld:pubmed |
| pubmed-article:32943 | pubmed:author | pubmed-author:FlynnS BSB | lld:pubmed |
| pubmed-article:32943 | pubmed:author | pubmed-author:GristwoodR... | lld:pubmed |
| pubmed-article:32943 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:32943 | pubmed:volume | 65 | lld:pubmed |
| pubmed-article:32943 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:32943 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:32943 | pubmed:pagination | 127-37 | lld:pubmed |
| pubmed-article:32943 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:32943 | pubmed:year | 1979 | lld:pubmed |
| pubmed-article:32943 | pubmed:articleTitle | Differentiation of the roles of histamine H1- and H2-receptors in the mediation of the effects of histamine in the isolated working heart of the guinea-pig. | lld:pubmed |
| pubmed-article:32943 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:32943 | pubmed:publicationType | In Vitro | lld:pubmed |
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