| pubmed-article:3288092 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3288092 | lifeskim:mentions | umls-concept:C0439857 | lld:lifeskim |
| pubmed-article:3288092 | lifeskim:mentions | umls-concept:C0598352 | lld:lifeskim |
| pubmed-article:3288092 | lifeskim:mentions | umls-concept:C0182537 | lld:lifeskim |
| pubmed-article:3288092 | pubmed:dateCreated | 1988-7-14 | lld:pubmed |
| pubmed-article:3288092 | pubmed:abstractText | Present evidence demonstrates that the Na-K pump rate is voltage dependent, whereas early work was largely inconclusive. The I-V relationship has a positive slope over a wide voltage range, and the existence of a negative slope region is now doubtful. Monotonic voltage dependence is consistent with the reaction cycle containing a single voltage-dependent step. Recent measurements suggest that this voltage-dependent step occurs during Na translocation and may be deocclusion of Na+. In addition, two results suggest that K translocation is voltage insensitive: (a) large positive potentials appear to have no influence on Rb-Rb exchange or associated conformational transitions; and (b) transient currents associated with Na translocation appear to involve movement of a single charge, which is sufficient for a 3Na-2K cycle. The simplest interpretation is that the pump's cation binding sites supply two negative charges. Pre-steady-state measurements demonstrate that Na translocation precedes the pump cycle's rate-limiting step, presumably K translocation. But, because K translocation seems voltage insensitive, the voltage dependence of the steady-state pump rate probably reflects that of the concentration of the intermediate entering this slow step. Further pump current and flux data (both transient and steady-state), carefully determined over a range of conditions, should increase our understanding of the voltage-dependent step(s) in the Na-K pump cycle. | lld:pubmed |
| pubmed-article:3288092 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3288092 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3288092 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3288092 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3288092 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3288092 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3288092 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3288092 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3288092 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3288092 | pubmed:issn | 0066-4278 | lld:pubmed |
| pubmed-article:3288092 | pubmed:author | pubmed-author:De WeerPP | lld:pubmed |
| pubmed-article:3288092 | pubmed:author | pubmed-author:GadsbyD CDC | lld:pubmed |
| pubmed-article:3288092 | pubmed:author | pubmed-author:RakowskiR FRF | lld:pubmed |
| pubmed-article:3288092 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3288092 | pubmed:volume | 50 | lld:pubmed |
| pubmed-article:3288092 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3288092 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3288092 | pubmed:pagination | 225-41 | lld:pubmed |
| pubmed-article:3288092 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:3288092 | pubmed:meshHeading | pubmed-meshheading:3288092-... | lld:pubmed |
| pubmed-article:3288092 | pubmed:meshHeading | pubmed-meshheading:3288092-... | lld:pubmed |
| pubmed-article:3288092 | pubmed:meshHeading | pubmed-meshheading:3288092-... | lld:pubmed |
| pubmed-article:3288092 | pubmed:meshHeading | pubmed-meshheading:3288092-... | lld:pubmed |
| pubmed-article:3288092 | pubmed:meshHeading | pubmed-meshheading:3288092-... | lld:pubmed |
| pubmed-article:3288092 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:3288092 | pubmed:articleTitle | Voltage dependence of the Na-K pump. | lld:pubmed |
| pubmed-article:3288092 | pubmed:affiliation | Department of Cell Biology and Physiology, Washington University, School of Medicine, St. Louis, Missouri 63110. | lld:pubmed |
| pubmed-article:3288092 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3288092 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3288092 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:3288092 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3288092 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3288092 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3288092 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3288092 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3288092 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3288092 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3288092 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3288092 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3288092 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3288092 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3288092 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3288092 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3288092 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3288092 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3288092 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3288092 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3288092 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3288092 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3288092 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3288092 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3288092 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3288092 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3288092 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3288092 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3288092 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3288092 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3288092 | lld:pubmed |
