| pubmed-article:328471 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:328471 | lifeskim:mentions | umls-concept:C0579233 | lld:lifeskim |
| pubmed-article:328471 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:328471 | lifeskim:mentions | umls-concept:C0453882 | lld:lifeskim |
| pubmed-article:328471 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:328471 | pubmed:dateCreated | 1977-9-22 | lld:pubmed |
| pubmed-article:328471 | pubmed:abstractText | The bactericidal activity of penicillin-aminoglycoside combinations was studied in 16 strains of Group B streptococci. Minimal inhibitory concentrations (MIC) against kanamycin or gentamicin were greater than 50 microgram/ml, whereas ampicillin or penicillin inhibitory concentrations were uniformly less than 0.1 microgram/ml. Although all strains had bactericidal concentrations (MBC) less than 0.1 microgram penicillin/ml, penicillin at a concentration equal to each strains respective MBC reduced inoculum colony forming units (CFU) 2 logs in only 6 of 16 strains in bactericidal kinetic studies. However, the addition of gentamicin in concentrations of 5.0 or 10.0 microgram/ml to penicillin markedly enhanced bactericidal activity in all strains tested. The addition of lower concentrations of gentamicin (1.0 microgram/ml) had minimal advantage over penicillin alone. No distinct advantage was noted for combinations including either ampicillin or kanamycin. The theoretical advantage of penicillin-aminoglycoside combinations in experimental conditions, suggests that the use of antibiotic combinations in clinical infections due to Group B streptococci, may result in a more rapid eradication of these organisms. | lld:pubmed |
| pubmed-article:328471 | pubmed:language | eng | lld:pubmed |
| pubmed-article:328471 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:328471 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:328471 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:328471 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:328471 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:328471 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:328471 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:328471 | pubmed:issn | 0021-8820 | lld:pubmed |
| pubmed-article:328471 | pubmed:author | pubmed-author:OverturfG DGD | lld:pubmed |
| pubmed-article:328471 | pubmed:author | pubmed-author:HorowitzMM | lld:pubmed |
| pubmed-article:328471 | pubmed:author | pubmed-author:WilkinsJJ | lld:pubmed |
| pubmed-article:328471 | pubmed:author | pubmed-author:SteinbergEE | lld:pubmed |
| pubmed-article:328471 | pubmed:author | pubmed-author:LeedomJJ | lld:pubmed |
| pubmed-article:328471 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:328471 | pubmed:volume | 30 | lld:pubmed |
| pubmed-article:328471 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:328471 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:328471 | pubmed:pagination | 513-8 | lld:pubmed |
| pubmed-article:328471 | pubmed:dateRevised | 2000-12-18 | lld:pubmed |
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| pubmed-article:328471 | pubmed:meshHeading | pubmed-meshheading:328471-D... | lld:pubmed |
| pubmed-article:328471 | pubmed:year | 1977 | lld:pubmed |
| pubmed-article:328471 | pubmed:articleTitle | Bactericidal studies of penicillin-gentamicin combinations against group B streptococci. | lld:pubmed |
| pubmed-article:328471 | pubmed:publicationType | Journal Article | lld:pubmed |
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