| pubmed-article:3280472 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3280472 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:3280472 | lifeskim:mentions | umls-concept:C0021759 | lld:lifeskim |
| pubmed-article:3280472 | lifeskim:mentions | umls-concept:C1707455 | lld:lifeskim |
| pubmed-article:3280472 | lifeskim:mentions | umls-concept:C1522428 | lld:lifeskim |
| pubmed-article:3280472 | lifeskim:mentions | umls-concept:C1155004 | lld:lifeskim |
| pubmed-article:3280472 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:3280472 | pubmed:dateCreated | 1988-4-29 | lld:pubmed |
| pubmed-article:3280472 | pubmed:abstractText | The B-cell differentiation-inducing activity of interleukin-1 (IL-1) was compared with that of T-cell replacing factor (TRF)/interleukin-5 (IL-5), which was originally described as a late-acting B-cell differentiation-inducing factor. Human recombinant IL-1 and murine recombinant TRF/IL-5 were used in this study. Purified B cells from non-primed or antigen-primed mice, LPS-stimulated B-cell blasts, and chronic B-cell leukaemia (BCL1) cells were used as the responding B-cell population. Addition of IL-1 to the culture of normal B-cells and sheep red blood cells (SRBC) induced a dose-dependent anti-SRBC IgM response, with maximal response at 100 U/ml, whereas the response induced by TRF/IL-5 was less than that induced by IL-1 and did not reach the maximum even at 100 U/ml. Addition of anti-IL-1 antibody, but not anti-TRF/IL-5 antibody or anti-IL-2 receptor antibody, inhibited IL-1-induced anti-SRBC responses. Depletion of cells adherent to Sephadex beads from splenic B cells showed no significant effect on the magnitude of the total responses. IL-1 could induce little, if any, differentiation in antigen-primed B cells, LPS-stimulated B-cell blasts, or BCL1 cells into antibody-secreting cells, whereas differentiation could be induced by low doses of TRF/IL-5 (1-2 U/ml). Of great interest is that suboptimal doses of IL-1 (10 U/ml) could synergize with TRF in the primary anti-SRBC PFC responses. Kinetic studies revealed that IL-1 acts on B cells for the first 2 days and TRF/IL-5 for the last 3 days in 5-day cultures of B cells. These results suggest that IL-1 acts primarily on resting B cells as a differentiation-inducing factor in the presence of antigen, and also acts as a 'priming' factor for TRF/IL-5. | lld:pubmed |
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| pubmed-article:3280472 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3280472 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3280472 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3280472 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3280472 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:3280472 | pubmed:issn | 0019-2805 | lld:pubmed |
| pubmed-article:3280472 | pubmed:author | pubmed-author:OkamuraHH | lld:pubmed |
| pubmed-article:3280472 | pubmed:author | pubmed-author:TakahashiTT | lld:pubmed |
| pubmed-article:3280472 | pubmed:author | pubmed-author:KoyamaNN | lld:pubmed |
| pubmed-article:3280472 | pubmed:author | pubmed-author:TakatsuKK | lld:pubmed |
| pubmed-article:3280472 | pubmed:author | pubmed-author:TominagaAA | lld:pubmed |
| pubmed-article:3280472 | pubmed:author | pubmed-author:HaradaNN | lld:pubmed |
| pubmed-article:3280472 | pubmed:author | pubmed-author:MitaSS | lld:pubmed |
| pubmed-article:3280472 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3280472 | pubmed:volume | 63 | lld:pubmed |
| pubmed-article:3280472 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3280472 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3280472 | pubmed:pagination | 277-83 | lld:pubmed |
| pubmed-article:3280472 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:3280472 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:3280472 | pubmed:articleTitle | Role of recombinant interleukin-1 compared to recombinant T-cell replacing factor/interleukin-5 in B-cell differentiation. | lld:pubmed |
| pubmed-article:3280472 | pubmed:affiliation | Department of Biology, Kumamoto University Medical School, Japan. | lld:pubmed |
| pubmed-article:3280472 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3280472 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:3280472 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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