| pubmed-article:3277185 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3277185 | lifeskim:mentions | umls-concept:C0205147 | lld:lifeskim |
| pubmed-article:3277185 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:3277185 | lifeskim:mentions | umls-concept:C0162768 | lld:lifeskim |
| pubmed-article:3277185 | lifeskim:mentions | umls-concept:C0205224 | lld:lifeskim |
| pubmed-article:3277185 | lifeskim:mentions | umls-concept:C0439828 | lld:lifeskim |
| pubmed-article:3277185 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:3277185 | pubmed:dateCreated | 1988-3-21 | lld:pubmed |
| pubmed-article:3277185 | pubmed:abstractText | The biological role of amino acid differences between the human 21-kDa Ha-ras protein (p21) and the human 23-kDa R-ras protein (p23) was investigated by engineering mutant Ha-ras p21 molecules containing divergent amino acid sequences from R-ras p23. Variant amino acids from R-ras p23 regions 1-30, 52-57, 67-78, 1-30 and 67-78 together, and 112-124 were substituted for the corresponding Ha-ras p21 amino acid regions 1-4, 26-31, 41-52, 1-4 and 41-52 together, and 86-98, respectively. Rat fibroblasts transfected with genes encoding these position-12 valine-substituted chimeric Ha-ras proteins displayed the same properties of morphological transformation and anchorage-independent growth as Ha-ras T24 oncogene-transformed fibroblasts. However, substitution of variant amino acids from the 80 C-terminal residues (amino acids 138-218) of R-ras p23 for the corresponding p21 amino acids (residues 112-189) inactivated the transforming activity of position-12 valine-substituted p21. The converse substitution of Ha-ras p21 C-terminal residues into R-ras p23 did not result in transformation by position-38 valine-substituted p23. These data are discussed in terms of the structure of ras proteins and the nature of interactions determining the specificity of effector function. | lld:pubmed |
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| pubmed-article:3277185 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3277185 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3277185 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3277185 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3277185 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:3277185 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:3277185 | pubmed:author | pubmed-author:GoeddelD VDV | lld:pubmed |
| pubmed-article:3277185 | pubmed:author | pubmed-author:LevinsonA DAD | lld:pubmed |
| pubmed-article:3277185 | pubmed:author | pubmed-author:OWENKK | lld:pubmed |
| pubmed-article:3277185 | pubmed:author | pubmed-author:RickettsMM | lld:pubmed |
| pubmed-article:3277185 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3277185 | pubmed:volume | 85 | lld:pubmed |
| pubmed-article:3277185 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3277185 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3277185 | pubmed:pagination | 1015-9 | lld:pubmed |
| pubmed-article:3277185 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:3277185 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:3277185 | pubmed:articleTitle | Chimeric proteins define variable and essential regions of Ha-ras-encoded protein. | lld:pubmed |
| pubmed-article:3277185 | pubmed:affiliation | Department of Molecular Biology, Genentech, Inc., South San Francisco, CA 94080. | lld:pubmed |
| pubmed-article:3277185 | pubmed:publicationType | Journal Article | lld:pubmed |
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