| pubmed-article:3265655 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3265655 | lifeskim:mentions | umls-concept:C0026724 | lld:lifeskim |
| pubmed-article:3265655 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:3265655 | lifeskim:mentions | umls-concept:C0450429 | lld:lifeskim |
| pubmed-article:3265655 | lifeskim:mentions | umls-concept:C0879551 | lld:lifeskim |
| pubmed-article:3265655 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:3265655 | lifeskim:mentions | umls-concept:C1704711 | lld:lifeskim |
| pubmed-article:3265655 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:3265655 | lifeskim:mentions | umls-concept:C0444498 | lld:lifeskim |
| pubmed-article:3265655 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:3265655 | pubmed:dateCreated | 1989-3-29 | lld:pubmed |
| pubmed-article:3265655 | pubmed:abstractText | Mucosal T cells in explants of human fetal small intestine (17-20 weeks gestation) in organ culture were activated in situ using monoclonal anti-CD3 antibody. Changes in the distribution of T cells within the mucosa, and their phenotype, were monitored by immunohistochemistry on frozen sections. Anti-CD3 stimulated T cells (as determined by expression of CD25) were predominantly in the lamina propria and were rarely seen in the epithelium. In control cultures, after 72 h, CD3+ IEL decreased to low numbers compared to day zero. However, in cultures treated with anti-CD3, IEL numbers were maintained and in some experiments significantly increased compared to day zero levels. At onset of culture 50-60% of CD3+ IEL were CD4-, 8-, and virtually all were HML-1+. The T cell infiltrate into the epithelium induced by activation of lamina propria T cells with anti-CD3 was also mostly CD3+, 4-, 8-, HML-1+. These experiments provide strong evidence that increases in IEL numbers can be a consequence of lamina propria T cell activation. | lld:pubmed |
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| pubmed-article:3265655 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3265655 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3265655 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3265655 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3265655 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:3265655 | pubmed:issn | 0009-9104 | lld:pubmed |
| pubmed-article:3265655 | pubmed:author | pubmed-author:SpencerJJ | lld:pubmed |
| pubmed-article:3265655 | pubmed:author | pubmed-author:MacDonaldT... | lld:pubmed |
| pubmed-article:3265655 | pubmed:author | pubmed-author:Cerf-Bensussa... | lld:pubmed |
| pubmed-article:3265655 | pubmed:author | pubmed-author:POPPR JRJJr | lld:pubmed |
| pubmed-article:3265655 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3265655 | pubmed:volume | 74 | lld:pubmed |
| pubmed-article:3265655 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3265655 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3265655 | pubmed:pagination | 216-22 | lld:pubmed |
| pubmed-article:3265655 | pubmed:dateRevised | 2010-8-25 | lld:pubmed |
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| pubmed-article:3265655 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:3265655 | pubmed:articleTitle | Stimulation of mucosal T cells in situ with anti-CD3 antibody: location of the activated T cells and their distribution within the mucosal micro-environment. | lld:pubmed |
| pubmed-article:3265655 | pubmed:affiliation | Department of Paediatric Gastroenterology, St. Bartholomew's Hospital, West Smithfield, London. | lld:pubmed |
| pubmed-article:3265655 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3265655 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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