| pubmed-article:3258496 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3258496 | lifeskim:mentions | umls-concept:C0036733 | lld:lifeskim |
| pubmed-article:3258496 | lifeskim:mentions | umls-concept:C0040018 | lld:lifeskim |
| pubmed-article:3258496 | lifeskim:mentions | umls-concept:C0699900 | lld:lifeskim |
| pubmed-article:3258496 | lifeskim:mentions | umls-concept:C0019137 | lld:lifeskim |
| pubmed-article:3258496 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:3258496 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:3258496 | lifeskim:mentions | umls-concept:C0449297 | lld:lifeskim |
| pubmed-article:3258496 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:3258496 | lifeskim:mentions | umls-concept:C0205214 | lld:lifeskim |
| pubmed-article:3258496 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:3258496 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:3258496 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:3258496 | pubmed:dateCreated | 1988-5-10 | lld:pubmed |
| pubmed-article:3258496 | pubmed:abstractText | The plasma clearance of 125I-labeled human heparin cofactor II and its complex with thrombin was studied in mice to determine whether a specific mechanism exists for the catabolism of the inhibitor-proteinase complex. Initial studies demonstrated that murine plasma contains a heparin cofactor II-like inhibitor as shown by the presence of a dermatan sulfate-sensitive thrombin inhibitor. Human heparin cofactor II cleared from the circulation of mice with an apparent half-life of 80 min while heparin cofactor II-thrombin complexes cleared with an apparent half-life of only 10 min. The specificity of the clearance mechanism was investigated by clearance competition studies involving coinjection of excess unlabeled heparin cofactor II-alpha-thrombin, antithrombin III-alpha-thrombin, or alpha 1-proteinase inhibitor-elastase, and by tissue distribution studies. The results demonstrated that the clearance of 125I-labeled heparin cofactor II-alpha-thrombin is a receptor-mediated process, and that the same hepatocyte receptor system recognizes complexes containing heparin cofactor II, antithrombin III, and alpha 1-proteinase inhibitor. | lld:pubmed |
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| pubmed-article:3258496 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3258496 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3258496 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3258496 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3258496 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:3258496 | pubmed:issn | 0003-9861 | lld:pubmed |
| pubmed-article:3258496 | pubmed:author | pubmed-author:PizzoS VSV | lld:pubmed |
| pubmed-article:3258496 | pubmed:author | pubmed-author:PrattC WCW | lld:pubmed |
| pubmed-article:3258496 | pubmed:author | pubmed-author:ChurchF CFC | lld:pubmed |
| pubmed-article:3258496 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3258496 | pubmed:volume | 262 | lld:pubmed |
| pubmed-article:3258496 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3258496 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3258496 | pubmed:pagination | 111-7 | lld:pubmed |
| pubmed-article:3258496 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:3258496 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:3258496 | pubmed:articleTitle | In vivo catabolism of heparin cofactor II and its complex with thrombin: evidence for a common receptor-mediated clearance pathway for three serine proteinase inhibitors. | lld:pubmed |
| pubmed-article:3258496 | pubmed:affiliation | Department of Biochemistry, Duke University Medical Center, Durham, North Carolina. | lld:pubmed |
| pubmed-article:3258496 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3258496 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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