| pubmed-article:3257683 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3257683 | lifeskim:mentions | umls-concept:C0021756 | lld:lifeskim |
| pubmed-article:3257683 | lifeskim:mentions | umls-concept:C0005841 | lld:lifeskim |
| pubmed-article:3257683 | lifeskim:mentions | umls-concept:C0206431 | lld:lifeskim |
| pubmed-article:3257683 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:3257683 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:3257683 | lifeskim:mentions | umls-concept:C0079411 | lld:lifeskim |
| pubmed-article:3257683 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:3257683 | pubmed:dateCreated | 1988-3-8 | lld:pubmed |
| pubmed-article:3257683 | pubmed:abstractText | To study the effect of blood transfusion (BT) on cell-mediated immunity, we examined the antigen presentation function of peritoneal macrophages and interleukin 2 (IL-2) generation by splenocytes. C3H/HEJ mice were transfused with 0.2 mL of fresh allogeneic blood obtained from C57BL/6 mice; they were killed on days 1, 3, and 7 after BT. A second group of C3H/HEJ mice was transfused with 0.2 mL/d of the same allogeneic blood on three successive days; they were killed on day 7 following the last BT. The antigen presentation function of peritoneal macrophages was measured by utilizing a D10.G4.1 T-helper cell clone; IL-2 activity in supernatants of concanavalin A-stimulated splenocytes was tested by utilizing an IL-2-dependent HT-2 cell line. The results indicate that although antigen presentation function remains unaffected after single and multiple BTs, the ability of splenocytes to generate IL-2 decreases significantly even after a single BT. Thus, the increased susceptibility to infection and the additional immune perturbations in malignant neoplasms following BT may be due in part to decreased IL-2 generation. | lld:pubmed |
| pubmed-article:3257683 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3257683 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3257683 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:3257683 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3257683 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3257683 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:3257683 | pubmed:issn | 0004-0010 | lld:pubmed |
| pubmed-article:3257683 | pubmed:author | pubmed-author:ChaudryI HIH | lld:pubmed |
| pubmed-article:3257683 | pubmed:author | pubmed-author:GehaA SAS | lld:pubmed |
| pubmed-article:3257683 | pubmed:author | pubmed-author:DeanR ERE | lld:pubmed |
| pubmed-article:3257683 | pubmed:author | pubmed-author:KisalaJ MJM | lld:pubmed |
| pubmed-article:3257683 | pubmed:author | pubmed-author:StephanR NRN | lld:pubmed |
| pubmed-article:3257683 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3257683 | pubmed:volume | 123 | lld:pubmed |
| pubmed-article:3257683 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3257683 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3257683 | pubmed:pagination | 235-40 | lld:pubmed |
| pubmed-article:3257683 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:3257683 | pubmed:meshHeading | pubmed-meshheading:3257683-... | lld:pubmed |
| pubmed-article:3257683 | pubmed:meshHeading | pubmed-meshheading:3257683-... | lld:pubmed |
| pubmed-article:3257683 | pubmed:meshHeading | pubmed-meshheading:3257683-... | lld:pubmed |
| pubmed-article:3257683 | pubmed:meshHeading | pubmed-meshheading:3257683-... | lld:pubmed |
| pubmed-article:3257683 | pubmed:meshHeading | pubmed-meshheading:3257683-... | lld:pubmed |
| pubmed-article:3257683 | pubmed:meshHeading | pubmed-meshheading:3257683-... | lld:pubmed |
| pubmed-article:3257683 | pubmed:meshHeading | pubmed-meshheading:3257683-... | lld:pubmed |
| pubmed-article:3257683 | pubmed:meshHeading | pubmed-meshheading:3257683-... | lld:pubmed |
| pubmed-article:3257683 | pubmed:meshHeading | pubmed-meshheading:3257683-... | lld:pubmed |
| pubmed-article:3257683 | pubmed:meshHeading | pubmed-meshheading:3257683-... | lld:pubmed |
| pubmed-article:3257683 | pubmed:meshHeading | pubmed-meshheading:3257683-... | lld:pubmed |
| pubmed-article:3257683 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:3257683 | pubmed:articleTitle | Effect of blood transfusion on antigen presentation function and on interleukin 2 generation. | lld:pubmed |
| pubmed-article:3257683 | pubmed:affiliation | Department of Surgery, Michigan State University, East Lansing 48824-1315. | lld:pubmed |
| pubmed-article:3257683 | pubmed:publicationType | Journal Article | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3257683 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3257683 | lld:pubmed |
