| pubmed-article:3257165 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3257165 | lifeskim:mentions | umls-concept:C0023434 | lld:lifeskim |
| pubmed-article:3257165 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:3257165 | lifeskim:mentions | umls-concept:C0178719 | lld:lifeskim |
| pubmed-article:3257165 | lifeskim:mentions | umls-concept:C0013089 | lld:lifeskim |
| pubmed-article:3257165 | lifeskim:mentions | umls-concept:C0870883 | lld:lifeskim |
| pubmed-article:3257165 | lifeskim:mentions | umls-concept:C0243144 | lld:lifeskim |
| pubmed-article:3257165 | lifeskim:mentions | umls-concept:C1704711 | lld:lifeskim |
| pubmed-article:3257165 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:3257165 | pubmed:dateCreated | 1988-2-23 | lld:pubmed |
| pubmed-article:3257165 | pubmed:abstractText | The toxicity of doxorubicin metabolites was evaluated on lymphocytes of B-cell chronic lymphocytic leukemia. Only doxorubicinol was found to be cytotoxic for these lymphocytes, whereas exposure to aglycones at concentrations as high as 5 microM for 1 h had no effect on the proliferative capacity of these cells. After exposure of cells to isomolar concentrations of doxorubicin or its metabolites, uptake/retention of doxorubicinol was 23% of doxorubicin, and uptake/retention of aglycones was 5 to 13% of doxorubicin. Seventy to 90% of doxorubicin and 60 to 90% of doxorubicinol taken up/retained by the cells were detected in the cell nuclear fraction, whereas only 20 to 40% of the aglycones were localized in the cell nucleus. Cytotoxicity of metabolites was generally related to the proportion of drug taken up/retained by the cells and localized to the nuclei. The low uptake and nuclear localization may be at least partially responsible for the lack of cytotoxicity of aglycones on B-lymphocytes from chronic lymphocytic leukemia. | lld:pubmed |
| pubmed-article:3257165 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3257165 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3257165 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3257165 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3257165 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3257165 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3257165 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3257165 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3257165 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:3257165 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:3257165 | pubmed:author | pubmed-author:HandeK RKR | lld:pubmed |
| pubmed-article:3257165 | pubmed:author | pubmed-author:BrennerD EDE | lld:pubmed |
| pubmed-article:3257165 | pubmed:author | pubmed-author:DessyprisE... | lld:pubmed |
| pubmed-article:3257165 | pubmed:author | pubmed-author:BaerM RMR | lld:pubmed |
| pubmed-article:3257165 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3257165 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:3257165 | pubmed:volume | 48 | lld:pubmed |
| pubmed-article:3257165 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3257165 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3257165 | pubmed:pagination | 503-6 | lld:pubmed |
| pubmed-article:3257165 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:3257165 | pubmed:meshHeading | pubmed-meshheading:3257165-... | lld:pubmed |
| pubmed-article:3257165 | pubmed:meshHeading | pubmed-meshheading:3257165-... | lld:pubmed |
| pubmed-article:3257165 | pubmed:meshHeading | pubmed-meshheading:3257165-... | lld:pubmed |
| pubmed-article:3257165 | pubmed:meshHeading | pubmed-meshheading:3257165-... | lld:pubmed |
| pubmed-article:3257165 | pubmed:meshHeading | pubmed-meshheading:3257165-... | lld:pubmed |
| pubmed-article:3257165 | pubmed:meshHeading | pubmed-meshheading:3257165-... | lld:pubmed |
| pubmed-article:3257165 | pubmed:meshHeading | pubmed-meshheading:3257165-... | lld:pubmed |
| pubmed-article:3257165 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:3257165 | pubmed:articleTitle | Uptake and intracellular distribution of doxorubicin metabolites in B-lymphocytes of chronic lymphocytic leukemia. | lld:pubmed |
| pubmed-article:3257165 | pubmed:affiliation | Division of Hematology, Veterans Administration Medical Center, Nashville, Tennessee 37203. | lld:pubmed |
| pubmed-article:3257165 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3257165 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:3257165 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3257165 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
