| pubmed-article:325170 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:325170 | lifeskim:mentions | umls-concept:C1704689 | lld:lifeskim |
| pubmed-article:325170 | lifeskim:mentions | umls-concept:C0567416 | lld:lifeskim |
| pubmed-article:325170 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:325170 | lifeskim:mentions | umls-concept:C2355612 | lld:lifeskim |
| pubmed-article:325170 | lifeskim:mentions | umls-concept:C0021013 | lld:lifeskim |
| pubmed-article:325170 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:325170 | pubmed:dateCreated | 1977-7-18 | lld:pubmed |
| pubmed-article:325170 | pubmed:abstractText | All A/J mice produce anti-p-azophenylarsonate (anti-Ar) antibodies, some of which share a cross-reactive idiotype. The idiotype can be suppressed by treatment with anti-idiotypic antiserum before immunization, although normal concentrations of anti-Ar antibodies are synthesized. We have previously reported that such suppressed mice, if hyperimmunized and then allowed to rest, contain up to 10% of splenic T cells which form rosettes with autologous RBC coated with Fab fragments of anti-Ar antibodies bearing the idiotype. Our present results indicate that the rosette-forming T cells include the idiotype-specific suppressor T-cell population. The suppressive activity is largely depleted by removal of the rosette-forming lymphocytes, and the rosettes themselves are highly suppressive. The data do not establish whether all of the idiotype-specific rosette-forming cells are suppressor cells. The system may provide a source of large numbers of suppressor cells for further study, and facilitate investigation of the mechanism of generation of idiotype-specific suppressor cells. | lld:pubmed |
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| pubmed-article:325170 | pubmed:language | eng | lld:pubmed |
| pubmed-article:325170 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:325170 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:325170 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:325170 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:325170 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:325170 | pubmed:author | pubmed-author:NisonoffAA | lld:pubmed |
| pubmed-article:325170 | pubmed:author | pubmed-author:OwenF LFL | lld:pubmed |
| pubmed-article:325170 | pubmed:author | pubmed-author:OSEMM | lld:pubmed |
| pubmed-article:325170 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:325170 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:325170 | pubmed:volume | 145 | lld:pubmed |
| pubmed-article:325170 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:325170 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:325170 | pubmed:pagination | 1559-66 | lld:pubmed |
| pubmed-article:325170 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:325170 | pubmed:year | 1977 | lld:pubmed |
| pubmed-article:325170 | pubmed:articleTitle | Presence on idiotype-specific suppressor T cells of receptors that interact with molecules bearing the idiotype. | lld:pubmed |
| pubmed-article:325170 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:325170 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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