Linked Life Data

3228669

Source:http://linkedlifedata.com/resource/pubmed/id/3228669

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:3228669rdf:typepubmed:Citationlld:pubmed
pubmed-article:3228669lifeskim:mentionsumls-concept:C0999699lld:lifeskim
pubmed-article:3228669lifeskim:mentionsumls-concept:C1267092lld:lifeskim
pubmed-article:3228669lifeskim:mentionsumls-concept:C0040578lld:lifeskim
pubmed-article:3228669lifeskim:mentionsumls-concept:C0001443lld:lifeskim
pubmed-article:3228669lifeskim:mentionsumls-concept:C0205409lld:lifeskim
pubmed-article:3228669lifeskim:mentionsumls-concept:C1280500lld:lifeskim
pubmed-article:3228669lifeskim:mentionsumls-concept:C0035028lld:lifeskim
pubmed-article:3228669lifeskim:mentionsumls-concept:C0243076lld:lifeskim
pubmed-article:3228669lifeskim:mentionsumls-concept:C1140999lld:lifeskim
pubmed-article:3228669pubmed:issue2lld:pubmed
pubmed-article:3228669pubmed:dateCreated1989-4-13lld:pubmed
pubmed-article:3228669pubmed:abstractText1. The effects of several adenosine analogues and antagonists on guinea-pig isolated trachea have been examined. 2. 5'-N-ethylcarboxamidoadenosine (NECA), 5'-N-methylcarboxamidoadenosine (MECA) and adenosine (in the presence and absence of dipyridamole) elicited concentration-dependent tracheal relaxation. 3. The R(-)- and S(+)-enantiomers of N6-(2-phenylisopropyl)adenosine (R-PIA and S-PIA respectively), N6-cyclohexyladenosine (CHA) and 2-chloroadenosine (CADO) caused contractions at low concentrations (0.05-2.0 microM), whereas at higher concentrations, relaxation resulted. 4. For tracheal relaxation, the adenosine analogues exhibited the following rank order of potency: NECA greater than CADO greater than R-PIA = MECA greater than S-PIA greater than adenosine. The rank order of potency for inducing contractions was R-PIA greater than CHA greater than CADO greater than S-PIA. These data suggest that relaxation is mediated by adenosine A2-receptors, whereas contraction is the result of activation of A1-receptors. 5. 8-Phenyltheophylline (8-PT), aminophylline, the triazoloquinazoline CGS 15943A and NPC205 (1,3-di-n-propyl-8-(4-hydroxyphenyl)xanthine) each inhibited the R-PIA-induced contractile response, whereas enprofylline was without effect. NPC205, aminophylline and 8-PT were competitive antagonists, but CGS15943A was non-competitive. 6. That the most potent antagonist was the A1-selective agent, NPC205 (pA2 = 7.80), further suggests that the contraction is mediated by A1-receptors. Moreover, NPC205 was 13 times more potent as an antagonist of R-PIA-induced contractions (A1) than of NECA-induced relaxations (A2). 7. The antagonists were also found to relax the trachea by an unknown mechanism. That enprofylline did not antagonize the R-PIA-induced contractions, but was 3-4 times more potent a tracheal relaxant than aminophylline, further suggests that a direct effect on airway smooth muscle, rather than antagonism of endogenous adenosine, is more relevant to the bronchodilator effect of alkylxanthines in the treatment of asthma.lld:pubmed
pubmed-article:3228669pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3228669pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3228669pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3228669pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3228669pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3228669pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3228669pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3228669pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3228669pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3228669pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3228669pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3228669pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3228669pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3228669pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3228669pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3228669pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3228669pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3228669pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3228669pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3228669pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3228669pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3228669pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3228669pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3228669pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3228669pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3228669pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3228669pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3228669pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3228669pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3228669pubmed:languageenglld:pubmed
pubmed-article:3228669pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3228669pubmed:citationSubsetIMlld:pubmed
pubmed-article:3228669pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3228669pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3228669pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3228669pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3228669pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3228669pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3228669pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3228669pubmed:statusMEDLINElld:pubmed
pubmed-article:3228669pubmed:monthOctlld:pubmed
pubmed-article:3228669pubmed:issn0007-1188lld:pubmed
pubmed-article:3228669pubmed:authorpubmed-author:FarmerS GSGlld:pubmed
pubmed-article:3228669pubmed:authorpubmed-author:WilkinsD EDElld:pubmed
pubmed-article:3228669pubmed:authorpubmed-author:CanningB JBJlld:pubmed
pubmed-article:3228669pubmed:issnTypePrintlld:pubmed
pubmed-article:3228669pubmed:volume95lld:pubmed
pubmed-article:3228669pubmed:ownerNLMlld:pubmed
pubmed-article:3228669pubmed:authorsCompleteYlld:pubmed
pubmed-article:3228669pubmed:pagination371-8lld:pubmed
pubmed-article:3228669pubmed:dateRevised2009-11-18lld:pubmed
pubmed-article:3228669pubmed:meshHeadingpubmed-meshheading:3228669-...lld:pubmed
pubmed-article:3228669pubmed:meshHeadingpubmed-meshheading:3228669-...lld:pubmed
pubmed-article:3228669pubmed:meshHeadingpubmed-meshheading:3228669-...lld:pubmed
pubmed-article:3228669pubmed:meshHeadingpubmed-meshheading:3228669-...lld:pubmed
pubmed-article:3228669pubmed:meshHeadingpubmed-meshheading:3228669-...lld:pubmed
pubmed-article:3228669pubmed:meshHeadingpubmed-meshheading:3228669-...lld:pubmed
pubmed-article:3228669pubmed:meshHeadingpubmed-meshheading:3228669-...lld:pubmed
pubmed-article:3228669pubmed:meshHeadingpubmed-meshheading:3228669-...lld:pubmed
pubmed-article:3228669pubmed:meshHeadingpubmed-meshheading:3228669-...lld:pubmed
pubmed-article:3228669pubmed:meshHeadingpubmed-meshheading:3228669-...lld:pubmed
pubmed-article:3228669pubmed:meshHeadingpubmed-meshheading:3228669-...lld:pubmed
pubmed-article:3228669pubmed:meshHeadingpubmed-meshheading:3228669-...lld:pubmed
pubmed-article:3228669pubmed:year1988lld:pubmed
pubmed-article:3228669pubmed:articleTitleAdenosine receptor-mediated contraction and relaxation of guinea-pig isolated tracheal smooth muscle: effects of adenosine antagonists.lld:pubmed
pubmed-article:3228669pubmed:affiliationNova Pharmaceutical Corporation, Baltimore, Maryland 21224.lld:pubmed
pubmed-article:3228669pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:3228669pubmed:publicationTypeIn Vitrolld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:3228669lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:3228669lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:3228669lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:3228669lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:3228669lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:3228669lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:3228669lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:3228669lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:3228669lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:3228669lld:pubmed