| pubmed-article:3223936 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3223936 | lifeskim:mentions | umls-concept:C0521066 | lld:lifeskim |
| pubmed-article:3223936 | lifeskim:mentions | umls-concept:C1704319 | lld:lifeskim |
| pubmed-article:3223936 | lifeskim:mentions | umls-concept:C0035203 | lld:lifeskim |
| pubmed-article:3223936 | lifeskim:mentions | umls-concept:C0020281 | lld:lifeskim |
| pubmed-article:3223936 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:3223936 | lifeskim:mentions | umls-concept:C0162324 | lld:lifeskim |
| pubmed-article:3223936 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:3223936 | pubmed:dateCreated | 1989-3-16 | lld:pubmed |
| pubmed-article:3223936 | pubmed:abstractText | 1. Respiration in the parasitic nematode worm Ascaridia galli was inhibited at O2 concentrations in excess of 255 microM, and an apparent Km,O2 of 174 microM was determined. 2. Mitochondria-enriched fractions isolated from the tissues of A. galli have much lower apparent Km,O2 values (approx. 5 microM). They produce H2O2 in the energized state; higher rates of H2O2 production were observed in the presence of the uncoupler carbonyl cyanide m-chlorophenylhydrazone. 3. Antimycin A inhibited respiration in muscle tissue mitochondria by 10%, but had no effect on respiration in gut + reproductive tissue mitochondria; the major portion of respiration in both types of mitochondria could be attributed to an alternative electron-transport pathway. 4. o-Hydroxydiphenyl, an inhibitor of alternative electron-transport pathways, inhibits respiration by 98% and completely inhibits the production of H2O2 in gut-plus-reproductive-tissue mitochondria; respiration and H2O2 production in muscle tissue mitochondria were inhibited by 90 and 86% respectively. 5. Another inhibitor of alternative electron transport, salicylhydroxamic acid, had the same effect as o-hydroxydiphenyl on H2O2 production and respiration in gut-plus-reproductive-tissue mitochondria. However, its effect on muscle tissue mitochondria was complex; a low concentration (0.35 mM) stimulated H2O2 production, whereas 3 mM inhibited respiration by 87% and prevented H2O2 production completely. 6. The similarities between the apparent Km,O2 values for H2O2 production and respiration in muscle mitochondria and in gut-plus-reproductive-tissue mitochondria suggests that the site of H2O2 production on the alternative electron-transport chain is cytochrome 'o'. 7. These results are discussed in relation to potential O2 toxicity in A. galli. | lld:pubmed |
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| pubmed-article:3223936 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3223936 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3223936 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3223936 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:3223936 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3223936 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:3223936 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:3223936 | pubmed:author | pubmed-author:FryMM | lld:pubmed |
| pubmed-article:3223936 | pubmed:author | pubmed-author:LloydDD | lld:pubmed |
| pubmed-article:3223936 | pubmed:author | pubmed-author:PagetT ATA | lld:pubmed |
| pubmed-article:3223936 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3223936 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:3223936 | pubmed:volume | 256 | lld:pubmed |
| pubmed-article:3223936 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3223936 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3223936 | pubmed:pagination | 633-9 | lld:pubmed |
| pubmed-article:3223936 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:3223936 | pubmed:meshHeading | pubmed-meshheading:3223936-... | lld:pubmed |
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| pubmed-article:3223936 | pubmed:meshHeading | pubmed-meshheading:3223936-... | lld:pubmed |
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| pubmed-article:3223936 | pubmed:meshHeading | pubmed-meshheading:3223936-... | lld:pubmed |
| pubmed-article:3223936 | pubmed:meshHeading | pubmed-meshheading:3223936-... | lld:pubmed |
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| pubmed-article:3223936 | pubmed:meshHeading | pubmed-meshheading:3223936-... | lld:pubmed |
| pubmed-article:3223936 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:3223936 | pubmed:articleTitle | The O2-dependence of respiration and H2O2 production in the parasitic nematode Ascaridia galli. | lld:pubmed |
| pubmed-article:3223936 | pubmed:affiliation | Department of Microbiology, University College, Cardiff, Wales, U.K. | lld:pubmed |
| pubmed-article:3223936 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3223936 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3223936 | lld:pubmed |
