| pubmed-article:3209396 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3209396 | lifeskim:mentions | umls-concept:C0015576 | lld:lifeskim |
| pubmed-article:3209396 | lifeskim:mentions | umls-concept:C1553325 | lld:lifeskim |
| pubmed-article:3209396 | lifeskim:mentions | umls-concept:C0002312 | lld:lifeskim |
| pubmed-article:3209396 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:3209396 | lifeskim:mentions | umls-concept:C0220908 | lld:lifeskim |
| pubmed-article:3209396 | lifeskim:mentions | umls-concept:C0043472 | lld:lifeskim |
| pubmed-article:3209396 | lifeskim:mentions | umls-concept:C0205175 | lld:lifeskim |
| pubmed-article:3209396 | pubmed:issue | 5-6 | lld:pubmed |
| pubmed-article:3209396 | pubmed:dateCreated | 1989-2-16 | lld:pubmed |
| pubmed-article:3209396 | pubmed:abstractText | In screening families for alpha-thalassemia (thal) by the Southern blot technique, several Laotian families were found which had anomalous zeta-globin haplotypes. The zeta-globin genes encode alpha-like embryonic hemoglobin subunits in the alpha-globin multigene complex on chromosome 16. There are normally two zeta-globin genes in this cluster: 5' zeta 2 and 3' psi zeta 1. In our study, six individuals in three families had triple zeta-globin genes. Another family revealed a novel quadruple zeta-globin arrangement. Two aberrant fragments were seen in Eco R1, Bam H1, Bgl II and Hind III digests using a zeta-globin gene probe. These anomalous bands were in the integral 10 kb range consistent with duplication of the zeta-globin region. This haplotype interpretation was confirmed by Southern blot analyses using double digestions hybridized to a cDNA zeta-gene probe, and Pvu II digests probed with a 5'-psi zeta 1 intergenic fragment. Proposed mechanisms of recombination and implications of this novel arrangement are discussed. | lld:pubmed |
| pubmed-article:3209396 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3209396 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3209396 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3209396 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3209396 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3209396 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3209396 | pubmed:issn | 0363-0269 | lld:pubmed |
| pubmed-article:3209396 | pubmed:author | pubmed-author:HuntJ AJA | lld:pubmed |
| pubmed-article:3209396 | pubmed:author | pubmed-author:HsiaY EYE | lld:pubmed |
| pubmed-article:3209396 | pubmed:author | pubmed-author:TitusE AEA | lld:pubmed |
| pubmed-article:3209396 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3209396 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:3209396 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3209396 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3209396 | pubmed:pagination | 539-50 | lld:pubmed |
| pubmed-article:3209396 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:3209396 | pubmed:meshHeading | pubmed-meshheading:3209396-... | lld:pubmed |
| pubmed-article:3209396 | pubmed:meshHeading | pubmed-meshheading:3209396-... | lld:pubmed |
| pubmed-article:3209396 | pubmed:meshHeading | pubmed-meshheading:3209396-... | lld:pubmed |
| pubmed-article:3209396 | pubmed:meshHeading | pubmed-meshheading:3209396-... | lld:pubmed |
| pubmed-article:3209396 | pubmed:meshHeading | pubmed-meshheading:3209396-... | lld:pubmed |
| pubmed-article:3209396 | pubmed:meshHeading | pubmed-meshheading:3209396-... | lld:pubmed |
| pubmed-article:3209396 | pubmed:meshHeading | pubmed-meshheading:3209396-... | lld:pubmed |
| pubmed-article:3209396 | pubmed:meshHeading | pubmed-meshheading:3209396-... | lld:pubmed |
| pubmed-article:3209396 | pubmed:meshHeading | pubmed-meshheading:3209396-... | lld:pubmed |
| pubmed-article:3209396 | pubmed:meshHeading | pubmed-meshheading:3209396-... | lld:pubmed |
| pubmed-article:3209396 | pubmed:meshHeading | pubmed-meshheading:3209396-... | lld:pubmed |
| pubmed-article:3209396 | pubmed:meshHeading | pubmed-meshheading:3209396-... | lld:pubmed |
| pubmed-article:3209396 | pubmed:meshHeading | pubmed-meshheading:3209396-... | lld:pubmed |
| pubmed-article:3209396 | pubmed:meshHeading | pubmed-meshheading:3209396-... | lld:pubmed |
| pubmed-article:3209396 | pubmed:meshHeading | pubmed-meshheading:3209396-... | lld:pubmed |
| pubmed-article:3209396 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:3209396 | pubmed:articleTitle | Alpha-thalassemia screening reveals quadruple zeta-globin genes in a Laotian family. | lld:pubmed |
| pubmed-article:3209396 | pubmed:affiliation | Department of Genetics, John Burns School of Medicine, University of Hawaii, Honolulu 96822. | lld:pubmed |
| pubmed-article:3209396 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3209396 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3209396 | lld:pubmed |
