Antitussive properties of levodropropizine.

Source:http://linkedlifedata.com/resource/pubmed/id/3196407

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Authors

Tonon GC, Melillo G, Malandrino S, Bestetti A, Borsh D, Giuliani P

Abstract

The antitussive activity of levodropropizine (S(-)-3-(4-phenyl-piperazin-1-yl)-propane-1,2-diol, DF 526), was evaluated in anaesthetized guinea-pigs and rabbits and in unanaesthetized guinea-pigs. Levodropropizine was shown to have good antitussive activity. Intravenously, it was 1/10 to 1/20 as active as codeine and comparable to dropropizine, from which it is derived, on mechanically and electrically induced coughing in rabbits and guinea-pigs. After oral administration to the guinea-pig the antitussive activity of levodropropizine was comparable with those of both dropropizine and codeine against coughing induced by irritant aerosols.

PMID
3196407

Publication types

Comparative Study