| pubmed-article:3186333 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3186333 | lifeskim:mentions | umls-concept:C0021289 | lld:lifeskim |
| pubmed-article:3186333 | lifeskim:mentions | umls-concept:C0034696 | lld:lifeskim |
| pubmed-article:3186333 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:3186333 | lifeskim:mentions | umls-concept:C0205464 | lld:lifeskim |
| pubmed-article:3186333 | lifeskim:mentions | umls-concept:C0205460 | lld:lifeskim |
| pubmed-article:3186333 | lifeskim:mentions | umls-concept:C0244221 | lld:lifeskim |
| pubmed-article:3186333 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:3186333 | pubmed:dateCreated | 1988-11-29 | lld:pubmed |
| pubmed-article:3186333 | pubmed:abstractText | Our study was undertaken to examine the pharmacological and biological effects of tin-protoporphyrin, a competitive inhibitor of heme oxygenase, on 5- or 6-day-old homozygous (j/j) Gunn rats with hereditary unconjugated hyperbilirubinemia. When j/j neonates were injected subcutaneously with 20 mumol of tin-protoporphyrin/kg of body weight, hepatic heme oxygenase activity decreased to 30% of the initial level 2 h after administration and remained low during the next 46 h. However, the reduction of serum bilirubin was more rapid and transient, reaching the minimum value (40% of the initial level) at 1 h and increasing thereafter at a rate almost comparable to that in nontreated j/j rats. The mortality rate of j/j rats was strikingly reduced by the administration of 1 to 100 mumol of tin-protoporphyrin/kg; the most effective dose was 5 mumol/kg (8% compared with 80% in non-treated j/j rats). However, the protective effect of tin-protoporphyrin on bilirubin cerebellopathy (cerebellar hypoplasia) was less marked than expected. Possible implications of our results are discussed. | lld:pubmed |
| pubmed-article:3186333 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3186333 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3186333 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3186333 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3186333 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3186333 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3186333 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3186333 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3186333 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3186333 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3186333 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3186333 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:3186333 | pubmed:issn | 0031-3998 | lld:pubmed |
| pubmed-article:3186333 | pubmed:author | pubmed-author:WatanabeKK | lld:pubmed |
| pubmed-article:3186333 | pubmed:author | pubmed-author:KashiwamataSS | lld:pubmed |
| pubmed-article:3186333 | pubmed:author | pubmed-author:KeinoHH | lld:pubmed |
| pubmed-article:3186333 | pubmed:author | pubmed-author:NagaeHH | lld:pubmed |
| pubmed-article:3186333 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3186333 | pubmed:volume | 24 | lld:pubmed |
| pubmed-article:3186333 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3186333 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3186333 | pubmed:pagination | 209-12 | lld:pubmed |
| pubmed-article:3186333 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:3186333 | pubmed:meshHeading | pubmed-meshheading:3186333-... | lld:pubmed |
| pubmed-article:3186333 | pubmed:meshHeading | pubmed-meshheading:3186333-... | lld:pubmed |
| pubmed-article:3186333 | pubmed:meshHeading | pubmed-meshheading:3186333-... | lld:pubmed |
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| pubmed-article:3186333 | pubmed:meshHeading | pubmed-meshheading:3186333-... | lld:pubmed |
| pubmed-article:3186333 | pubmed:meshHeading | pubmed-meshheading:3186333-... | lld:pubmed |
| pubmed-article:3186333 | pubmed:meshHeading | pubmed-meshheading:3186333-... | lld:pubmed |
| pubmed-article:3186333 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:3186333 | pubmed:articleTitle | Pharmacological and biological effects of tin-protoporphyrin on neonatal hyperbilirubinemic Gunn rats. | lld:pubmed |
| pubmed-article:3186333 | pubmed:affiliation | Department of Pediatrics, Nagoya University School of Medicine, Japan. | lld:pubmed |
| pubmed-article:3186333 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3186333 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
