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pubmed-article:3182490pubmed:abstractTextTo study air-mucus interaction as a possible mechanism of tracheal mucus transport and to test the validity of using surface tracer displacement to indicate bulk mucus transport, we performed a combined experimental-theoretical study. We hypothesized that the mucus mass is moved by the difference between expiratory and inspiratory velocities. The rate of transport of a layer of simulated mucus lining the bottom of a rectangular trough was measured in two ways during oscillatory air flow. Peak velocity ratios (R) from 1.0 to 2.0, frequencies (f) between 7 and 13 Hz, and tidal volumes (VT) between 50 and 100 ml were generated by a custom-made pump. The experimental results demonstrate that measuring the displacement of a tracer deposited on the surface of the mucus layer is equivalent to measuring bulk mucus movement by weight. Moreover the measured mucus velocities (micron) correlate well with a theoretical model which predicts that micron is proportional to delta VT f1.5 (R-1). These results suggest that shearing at the air-mucus interface could be a significant factor in the enhanced tracheal mucus clearance during high-frequency chest wall oscillation.lld:pubmed
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pubmed-article:3182490pubmed:authorpubmed-author:KingMMlld:pubmed
pubmed-article:3182490pubmed:authorpubmed-author:WeberM EMElld:pubmed
pubmed-article:3182490pubmed:authorpubmed-author:ChangH KHKlld:pubmed
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pubmed-article:3182490pubmed:volume65lld:pubmed
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pubmed-article:3182490pubmed:pagination1203-9lld:pubmed
pubmed-article:3182490pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:3182490pubmed:year1988lld:pubmed
pubmed-article:3182490pubmed:articleTitleMucus transport by high-frequency nonsymmetrical oscillatory airflow.lld:pubmed
pubmed-article:3182490pubmed:affiliationDepartment of Biomedical Engineering, University of Southern California, Los Angeles 90089-1451.lld:pubmed
pubmed-article:3182490pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:3182490pubmed:publicationTypeIn Vitrolld:pubmed