| pubmed-article:3168153 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3168153 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:3168153 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:3168153 | lifeskim:mentions | umls-concept:C0042036 | lld:lifeskim |
| pubmed-article:3168153 | lifeskim:mentions | umls-concept:C0221102 | lld:lifeskim |
| pubmed-article:3168153 | lifeskim:mentions | umls-concept:C0008838 | lld:lifeskim |
| pubmed-article:3168153 | lifeskim:mentions | umls-concept:C0242958 | lld:lifeskim |
| pubmed-article:3168153 | lifeskim:mentions | umls-concept:C0022702 | lld:lifeskim |
| pubmed-article:3168153 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:3168153 | lifeskim:mentions | umls-concept:C0205431 | lld:lifeskim |
| pubmed-article:3168153 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:3168153 | pubmed:dateCreated | 1988-11-8 | lld:pubmed |
| pubmed-article:3168153 | pubmed:abstractText | The main adduct of cis-diamminedichloroplatinum(II) (cis-Pt) with DNA, cis-[Pt(NH3)2(dGpdG)], was administered i.p. to rats. Urine was collected daily for 4 days. The adduct was purified by a weak cation exchanger and quantitated by HPLC with UV detection. The recovery of the adduct was 30.0 +/- 7.0% (mean +/- SEM). The main reason for the low recovery was the chemical instability of cis-[Pt(NH3)2 (dGpdG)] in urine as shown in an in vitro incubation. Adjusted for this instability the recovery in urine was greater than 70% of the dose. When cis-Pt-DNA (the molar ratio of cis-Pt to nucleotide = 1:50) was administered i.p. to rats only 1.25 +/- 0.23% of platinum was excreted in urine in the form of cis-[Pt(NH3)2(dGpdG)] and cis-[Pt(NH3)2(dApdG)] during the first 4 days. If the removal of the cis-Pt-DNA adducts from human tissues is to be followed, their possible slow excretion and chemical instability in urine needs to be considered. | lld:pubmed |
| pubmed-article:3168153 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3168153 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3168153 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3168153 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3168153 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3168153 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3168153 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3168153 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3168153 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3168153 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:3168153 | pubmed:issn | 0143-3334 | lld:pubmed |
| pubmed-article:3168153 | pubmed:author | pubmed-author:HemminkiKK | lld:pubmed |
| pubmed-article:3168153 | pubmed:author | pubmed-author:TakakiTT | lld:pubmed |
| pubmed-article:3168153 | pubmed:author | pubmed-author:LaatikainenRR | lld:pubmed |
| pubmed-article:3168153 | pubmed:author | pubmed-author:FörstiAA | lld:pubmed |
| pubmed-article:3168153 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3168153 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:3168153 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3168153 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3168153 | pubmed:pagination | 1745-8 | lld:pubmed |
| pubmed-article:3168153 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:3168153 | pubmed:meshHeading | pubmed-meshheading:3168153-... | lld:pubmed |
| pubmed-article:3168153 | pubmed:meshHeading | pubmed-meshheading:3168153-... | lld:pubmed |
| pubmed-article:3168153 | pubmed:meshHeading | pubmed-meshheading:3168153-... | lld:pubmed |
| pubmed-article:3168153 | pubmed:meshHeading | pubmed-meshheading:3168153-... | lld:pubmed |
| pubmed-article:3168153 | pubmed:meshHeading | pubmed-meshheading:3168153-... | lld:pubmed |
| pubmed-article:3168153 | pubmed:meshHeading | pubmed-meshheading:3168153-... | lld:pubmed |
| pubmed-article:3168153 | pubmed:meshHeading | pubmed-meshheading:3168153-... | lld:pubmed |
| pubmed-article:3168153 | pubmed:meshHeading | pubmed-meshheading:3168153-... | lld:pubmed |
| pubmed-article:3168153 | pubmed:meshHeading | pubmed-meshheading:3168153-... | lld:pubmed |
| pubmed-article:3168153 | pubmed:meshHeading | pubmed-meshheading:3168153-... | lld:pubmed |
| pubmed-article:3168153 | pubmed:meshHeading | pubmed-meshheading:3168153-... | lld:pubmed |
| pubmed-article:3168153 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:3168153 | pubmed:articleTitle | Excretion kinetics of the DNA adducts of cis-diamminedichloroplatinum(II) formed in vitro in rat urine. | lld:pubmed |
| pubmed-article:3168153 | pubmed:affiliation | Institute of Occupational Health, Helsinki, Finland. | lld:pubmed |
| pubmed-article:3168153 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3168153 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
