| pubmed-article:3166905 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3166905 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:3166905 | lifeskim:mentions | umls-concept:C0007102 | lld:lifeskim |
| pubmed-article:3166905 | lifeskim:mentions | umls-concept:C0334227 | lld:lifeskim |
| pubmed-article:3166905 | lifeskim:mentions | umls-concept:C0021747 | lld:lifeskim |
| pubmed-article:3166905 | lifeskim:mentions | umls-concept:C0026249 | lld:lifeskim |
| pubmed-article:3166905 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:3166905 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:3166905 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:3166905 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:3166905 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:3166905 | pubmed:dateCreated | 1988-11-21 | lld:pubmed |
| pubmed-article:3166905 | pubmed:abstractText | Recombinant human interferon alpha inhibits growth of a human colon cancer cell line, Colo 205. To explore the mechanisms of IFN induced growth inhibition, quiescent Colo 205 cells were stimulated to proliferate in serum-free media by defined growth factors. Addition of insulin, transferrin and selenium (ITS) stimulated DNA synthesis, as measured by 3H-thymidine incorporation, in a dose-dependent manner. IFN-alpha (at concentrations greater than 100 U ml-1) inhibited ITS stimulated DNA synthesis by 63%. Inhibition of cell cycle traverse was confirmed by flow cytometric analysis. Although IFN inhibited growth of ITS-treated cells, steady state levels of c-myc mRNA remained above levels observed in unstimulated cells. IFN inhibited DNA synthesis only when added prior to mitogen stimulation. IFN, added 6 h after exposure of quiescent cells to ITS, failed to inhibit cell growth. Addition of increasing concentrations of ITS failed to overcome the IFN-induced growth inhibition. These results suggest IFN may inhibit cell growth in part by antagonizing the action of growth factors. | lld:pubmed |
| pubmed-article:3166905 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3166905 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3166905 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3166905 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3166905 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3166905 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3166905 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3166905 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3166905 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3166905 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3166905 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3166905 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3166905 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3166905 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3166905 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3166905 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3166905 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3166905 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3166905 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3166905 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3166905 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3166905 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3166905 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3166905 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3166905 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3166905 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3166905 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3166905 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3166905 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3166905 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3166905 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3166905 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3166905 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3166905 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:3166905 | pubmed:issn | 0007-0920 | lld:pubmed |
| pubmed-article:3166905 | pubmed:author | pubmed-author:CondonM EME | lld:pubmed |
| pubmed-article:3166905 | pubmed:author | pubmed-author:HamburgerA... | lld:pubmed |
| pubmed-article:3166905 | pubmed:author | pubmed-author:O'DonnellKK | lld:pubmed |
| pubmed-article:3166905 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3166905 | pubmed:volume | 58 | lld:pubmed |
| pubmed-article:3166905 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3166905 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3166905 | pubmed:pagination | 147-51 | lld:pubmed |
| pubmed-article:3166905 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:3166905 | pubmed:meshHeading | pubmed-meshheading:3166905-... | lld:pubmed |
| pubmed-article:3166905 | pubmed:meshHeading | pubmed-meshheading:3166905-... | lld:pubmed |
| pubmed-article:3166905 | pubmed:meshHeading | pubmed-meshheading:3166905-... | lld:pubmed |
| pubmed-article:3166905 | pubmed:meshHeading | pubmed-meshheading:3166905-... | lld:pubmed |
| pubmed-article:3166905 | pubmed:meshHeading | pubmed-meshheading:3166905-... | lld:pubmed |
| pubmed-article:3166905 | pubmed:meshHeading | pubmed-meshheading:3166905-... | lld:pubmed |
| pubmed-article:3166905 | pubmed:meshHeading | pubmed-meshheading:3166905-... | lld:pubmed |
| pubmed-article:3166905 | pubmed:meshHeading | pubmed-meshheading:3166905-... | lld:pubmed |
| pubmed-article:3166905 | pubmed:meshHeading | pubmed-meshheading:3166905-... | lld:pubmed |
| pubmed-article:3166905 | pubmed:meshHeading | pubmed-meshheading:3166905-... | lld:pubmed |
| pubmed-article:3166905 | pubmed:meshHeading | pubmed-meshheading:3166905-... | lld:pubmed |
| pubmed-article:3166905 | pubmed:meshHeading | pubmed-meshheading:3166905-... | lld:pubmed |
| pubmed-article:3166905 | pubmed:meshHeading | pubmed-meshheading:3166905-... | lld:pubmed |
| pubmed-article:3166905 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:3166905 | pubmed:articleTitle | Inhibition of mitogen stimulated growth of human colon cancer cells by interferon. | lld:pubmed |
| pubmed-article:3166905 | pubmed:affiliation | University of Maryland Cancer Center, Baltimore 21201. | lld:pubmed |
| pubmed-article:3166905 | pubmed:publicationType | Journal Article | lld:pubmed |
