Linked Life Data

3164708

Source:http://linkedlifedata.com/resource/pubmed/id/3164708

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pubmed-article:3164708pubmed:abstractTextWe have previously shown that a stroma-associated paracrine influence may occur in the human breast. In particular, human breast fibroblasts secrete a factor which stimulates reductive 17 beta-oestradiol dehydrogenase (HSD) activity, thereby regulating tissue concentrations of 17 beta-oestradiol. We report here the results of experiments designed to establish the nature of the enzyme activity stimulating factor. In vitro cell culture techniques were used, in which human breast fibroblast-conditioned medium was used to grow the human breast cancer cell line, MCF-7, for 6 days, after which the reductive HSD activity of the monolayers was assessed. The fibroblastic reductive HSD stimulating factor was found to be a trypsin-sensitive polypeptide. The polypeptide eluted from a Sephadex G-75 column as a peak corresponding to a molecular weight of about 50 kDa. The polypeptide exerts its effects by altering the Vmax of 2 of the cytosolic forms of HSD within MCF-7 cells. This is achieved by a protein-synthesis-dependent but calmodulin-independent mechanism. These results provide further evidence of a paracrine effect by stromal tissue within the human breast and have important implications with respect to the aetiology and treatment of breast cancer.lld:pubmed
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pubmed-article:3164708pubmed:pagination119-22lld:pubmed
pubmed-article:3164708pubmed:dateRevised2007-7-24lld:pubmed
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pubmed-article:3164708pubmed:year1988lld:pubmed
pubmed-article:3164708pubmed:articleTitleParacrine influence of human breast stromal fibroblasts on breast epithelial cells: secretion of a polypeptide which stimulates reductive 17 beta-oestradiol dehydrogenase activity.lld:pubmed
pubmed-article:3164708pubmed:affiliationDepartment of Chemical Pathology, St. Mary's Hospital Medical School, London, UK.lld:pubmed
pubmed-article:3164708pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:3164708pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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