| pubmed-article:3162042 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3162042 | lifeskim:mentions | umls-concept:C0392360 | lld:lifeskim |
| pubmed-article:3162042 | lifeskim:mentions | umls-concept:C0449295 | lld:lifeskim |
| pubmed-article:3162042 | lifeskim:mentions | umls-concept:C0810126 | lld:lifeskim |
| pubmed-article:3162042 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:3162042 | pubmed:dateCreated | 1985-10-9 | lld:pubmed |
| pubmed-article:3162042 | pubmed:abstractText | Experimental studies in dogs with coronary thrombi induced by copper wire confirmed the optimal method of intracoronary thrombolysis, and showed that a high-dose, brief intravenous infusion of urokinase can lead to recanalization. The thrombolytic effects of intracoronary thrombolysin at a rate of 50 IU/kg over 10 minutes are similar to the effects of intracoronary urokinase at a rate 500 IU/kg over 20 minutes. Overall reperfusion rates of 83-86% have been achieved. These results indicate that the thrombolytic effect of thrombolysin is 20 times stronger than that of urokinase. The effect of a brief intravenous infusion of urokinase was less than that of intracoronary urokinase. The reperfusion rate in the same experimental model was 40%. Later, a clinical trial of intracoronary urokinase was performed in 47 patients with acute myocardial infarction who were admitted within 12 hours of the onset of symptoms. In 25 of 33 (75.8%) patients with complete occlusion, selective or ostial infusion of urokinase 500 IU/kg over 20 minutes was successful. When given intravenously, recanalization was achieved in 11 of 15 (73%) patients with complete occlusion who were admitted within 6 hours. Both reperfusion rates were similar except for dosage and the duration of infusion. | lld:pubmed |
| pubmed-article:3162042 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3162042 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3162042 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3162042 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3162042 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3162042 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3162042 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3162042 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:3162042 | pubmed:issn | 0047-1828 | lld:pubmed |
| pubmed-article:3162042 | pubmed:author | pubmed-author:KajiwaraNN | lld:pubmed |
| pubmed-article:3162042 | pubmed:author | pubmed-author:SatohYY | lld:pubmed |
| pubmed-article:3162042 | pubmed:author | pubmed-author:AndohTT | lld:pubmed |
| pubmed-article:3162042 | pubmed:author | pubmed-author:KanmatsuseKK | lld:pubmed |
| pubmed-article:3162042 | pubmed:author | pubmed-author:OnikuraSS | lld:pubmed |
| pubmed-article:3162042 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3162042 | pubmed:volume | 49 | lld:pubmed |
| pubmed-article:3162042 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3162042 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3162042 | pubmed:pagination | 597-604 | lld:pubmed |
| pubmed-article:3162042 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:3162042 | pubmed:meshHeading | pubmed-meshheading:3162042-... | lld:pubmed |
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| pubmed-article:3162042 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:3162042 | pubmed:articleTitle | Indications for and limitations of coronary thrombolysis. | lld:pubmed |
| pubmed-article:3162042 | pubmed:publicationType | Journal Article | lld:pubmed |
