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pubmed-article:31474pubmed:abstractTextThe effect of the introduction of a 2-methoxy substituent on the beta-adrenergic antagonistic properties of a series of 3- and 4-substituted phenylethanolamines (1) was studied. Both the series of bromo- and methyl-substituted compounds behaved similarly, indicating that electronic forces are not significant in determining beta-adrenergic antagonist activity. When compared with the corresponding phenylethanolamines without a 2-methoxy substitutent, the 2-methoxy-4-substituted derivatives (3a and 3d) had enhanced potency and selectivity but the 2,3- (3b and 3e) and the 2,5-disubstitution patterns (3c and 3f) showed a loss of activity. The inconsistent changes in activity prevented any firm conclusions being made about the effect of the ether oxygen and the beta-adrenoceptor antagonistic activity of phenoxypropanolamines.lld:pubmed
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pubmed-article:31474pubmed:monthOctlld:pubmed
pubmed-article:31474pubmed:issn0022-2623lld:pubmed
pubmed-article:31474pubmed:authorpubmed-author:WilliamsL RLRlld:pubmed
pubmed-article:31474pubmed:authorpubmed-author:LimC HCHlld:pubmed
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pubmed-article:31474pubmed:authorpubmed-author:LettsG LGLlld:pubmed
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pubmed-article:31474pubmed:volume21lld:pubmed
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pubmed-article:31474pubmed:pagination1081-4lld:pubmed
pubmed-article:31474pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:31474pubmed:year1978lld:pubmed
pubmed-article:31474pubmed:articleTitle2-Methoxyphenylethanolamines, potential beta-adrenergic blocking agents.lld:pubmed
pubmed-article:31474pubmed:publicationTypeJournal Articlelld:pubmed
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