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pubmed-article:3143801pubmed:abstractTextUsing a panel of antibodies specific for H and L chain variable region subgroups, a panel of human monoclonal cold agglutinin (CA) and rheumatoid factor (RF) autoantibodies were analyzed. The vast majority of the two types of autoantibodies utilized VkIII L chains, many of which probably derive from the Humkv325 gene. However, while most RFs (77%) utilized VHI H chains, all the CAs used VHII subgroup H chains. These results are consistent with a model of autoantibody generation, wherein binding specificity is H chain defined in a set of antibodies that use a multipotential L chain.lld:pubmed
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pubmed-article:3143801pubmed:articleTitleDistinct patterns of heavy chain variable region subgroup use by human monoclonal autoantibodies of different specificity.lld:pubmed
pubmed-article:3143801pubmed:affiliationDepartment of Basic and Clinical Research, Research Institute of Scripps Clinic, La Jolla, California 92037.lld:pubmed
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pubmed-article:3143801pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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