| pubmed-article:3143697 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3143697 | lifeskim:mentions | umls-concept:C1123023 | lld:lifeskim |
| pubmed-article:3143697 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:3143697 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:3143697 | lifeskim:mentions | umls-concept:C0040549 | lld:lifeskim |
| pubmed-article:3143697 | lifeskim:mentions | umls-concept:C0041370 | lld:lifeskim |
| pubmed-article:3143697 | lifeskim:mentions | umls-concept:C1304606 | lld:lifeskim |
| pubmed-article:3143697 | lifeskim:mentions | umls-concept:C0058309 | lld:lifeskim |
| pubmed-article:3143697 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:3143697 | pubmed:dateCreated | 1989-1-23 | lld:pubmed |
| pubmed-article:3143697 | pubmed:abstractText | Dinophysistoxin-1, 35-methylokadaic acid, is a causative agent of diarrhetic shellfish poisoning. The biological activities and tumor-promoting activity of dinophysistoxin-1 were studied together with those of okadaic acid and 7-O-palmitoyl okadaic acid. Dinophysistoxin-1 is a skin irritant and induces ornithine decarboxylase in mouse skin with the same potency as okadaic acid. 7-O-Palmitoyl okadaic acid induced a lower activity than the other compounds. Dinophysistoxin-1 inhibited the specific [3H]okadaic acid binding to a particulate fraction of mouse epidermis. The binding affinities of dinophysistoxin-1 and okadaic acid to a particulate fraction were almost the same. Dinophysistoxin-1 showed a tumor-promoting activity as strong as that of okadaic acid in a two-stage carcinogenesis experiment on mouse skin. The percentages of tumor-bearing mice in the groups treated with 100 micrograms of 7,12-dimethylbenz[a]anthracene (DMBA) followed by 5 micrograms of dinophysistoxin-1, twice a week, and with DMBA followed by 5 micrograms of okadaic acid twice a week were 86.7% and 80.0% in week 30, respectively. The average number of tumors per mouse was 4.6 in the former group and 3.9 in the latter. Dinophysistoxin-1 and okadaic acid act on cells through different pathways from the 12-O-tetradecanoylphorbol-13-acetate-type tumor promoters. | lld:pubmed |
| pubmed-article:3143697 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3143697 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3143697 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3143697 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3143697 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:3143697 | pubmed:issn | 0910-5050 | lld:pubmed |
| pubmed-article:3143697 | pubmed:author | pubmed-author:YasumotoTT | lld:pubmed |
| pubmed-article:3143697 | pubmed:author | pubmed-author:YamadaKK | lld:pubmed |
| pubmed-article:3143697 | pubmed:author | pubmed-author:TakagiKK | lld:pubmed |
| pubmed-article:3143697 | pubmed:author | pubmed-author:MurataMM | lld:pubmed |
| pubmed-article:3143697 | pubmed:author | pubmed-author:YoshizawaSS | lld:pubmed |
| pubmed-article:3143697 | pubmed:author | pubmed-author:FujikiHH | lld:pubmed |
| pubmed-article:3143697 | pubmed:author | pubmed-author:UdeJJ | lld:pubmed |
| pubmed-article:3143697 | pubmed:author | pubmed-author:SuganumaMM | lld:pubmed |
| pubmed-article:3143697 | pubmed:author | pubmed-author:WakamatsuKK | lld:pubmed |
| pubmed-article:3143697 | pubmed:author | pubmed-author:SuguriHH | lld:pubmed |
| pubmed-article:3143697 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3143697 | pubmed:volume | 79 | lld:pubmed |
| pubmed-article:3143697 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3143697 | pubmed:authorsComplete | N | lld:pubmed |
| pubmed-article:3143697 | pubmed:pagination | 1089-93 | lld:pubmed |
| pubmed-article:3143697 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:3143697 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:3143697 | pubmed:articleTitle | Diarrhetic shellfish toxin, dinophysistoxin-1, is a potent tumor promoter on mouse skin. | lld:pubmed |
| pubmed-article:3143697 | pubmed:affiliation | Cancer Prevention Division, National Cancer Center Research Institute, Tokyo. | lld:pubmed |
| pubmed-article:3143697 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3143697 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:3143697 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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