| pubmed-article:3142215 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3142215 | lifeskim:mentions | umls-concept:C0003451 | lld:lifeskim |
| pubmed-article:3142215 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:3142215 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:3142215 | lifeskim:mentions | umls-concept:C0021745 | lld:lifeskim |
| pubmed-article:3142215 | lifeskim:mentions | umls-concept:C1179435 | lld:lifeskim |
| pubmed-article:3142215 | lifeskim:mentions | umls-concept:C0002199 | lld:lifeskim |
| pubmed-article:3142215 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:3142215 | lifeskim:mentions | umls-concept:C0678226 | lld:lifeskim |
| pubmed-article:3142215 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:3142215 | lifeskim:mentions | umls-concept:C1705248 | lld:lifeskim |
| pubmed-article:3142215 | lifeskim:mentions | umls-concept:C1548799 | lld:lifeskim |
| pubmed-article:3142215 | lifeskim:mentions | umls-concept:C1524073 | lld:lifeskim |
| pubmed-article:3142215 | lifeskim:mentions | umls-concept:C0449432 | lld:lifeskim |
| pubmed-article:3142215 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:3142215 | pubmed:dateCreated | 1988-12-12 | lld:pubmed |
| pubmed-article:3142215 | pubmed:abstractText | The finding that interferon-gamma (IFN-gamma) may require two rounds of protein synthesis to induce the antiviral state raises the possibility that this IFN may not be directly antiviral. We, therefore, examined the possibility that IFN-gamma induces one or both of the other IFNs (alpha and/or beta) which in turn induce the antiviral state. Evidence is presented showing that under certain conditions a large portion of IFN-gamma's antiviral activity in mouse L-929 cells is mediated by its induction of IFN-alpha based on the findings that: 1) the antiviral activity of IFN-gamma in cells at low densities can be blocked by poly and monoclonal antibody to IFN-alpha and, 2) IFN-alpha can be demonstrated in the supernatant fluids of IFN-gamma treated cells. This report raises the possibility that a major antiviral mechanism of IFN-gamma is via induction of IFN-alpha in the mouse system. If the majority of the antiviral activity of IFN-gamma is via induction of other IFNs, then the role and mechanism of IFN-gamma might have to be reevaluated. | lld:pubmed |
| pubmed-article:3142215 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3142215 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3142215 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3142215 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3142215 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3142215 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3142215 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3142215 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3142215 | pubmed:issn | 0393-974X | lld:pubmed |
| pubmed-article:3142215 | pubmed:author | pubmed-author:BaronSS | lld:pubmed |
| pubmed-article:3142215 | pubmed:author | pubmed-author:HughesT KTK | lld:pubmed |
| pubmed-article:3142215 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3142215 | pubmed:volume | 1 | lld:pubmed |
| pubmed-article:3142215 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3142215 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3142215 | pubmed:pagination | 29-32 | lld:pubmed |
| pubmed-article:3142215 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:3142215 | pubmed:meshHeading | pubmed-meshheading:3142215-... | lld:pubmed |
| pubmed-article:3142215 | pubmed:meshHeading | pubmed-meshheading:3142215-... | lld:pubmed |
| pubmed-article:3142215 | pubmed:meshHeading | pubmed-meshheading:3142215-... | lld:pubmed |
| pubmed-article:3142215 | pubmed:meshHeading | pubmed-meshheading:3142215-... | lld:pubmed |
| pubmed-article:3142215 | pubmed:meshHeading | pubmed-meshheading:3142215-... | lld:pubmed |
| pubmed-article:3142215 | pubmed:meshHeading | pubmed-meshheading:3142215-... | lld:pubmed |
| pubmed-article:3142215 | pubmed:meshHeading | pubmed-meshheading:3142215-... | lld:pubmed |
| pubmed-article:3142215 | pubmed:meshHeading | pubmed-meshheading:3142215-... | lld:pubmed |
| pubmed-article:3142215 | pubmed:meshHeading | pubmed-meshheading:3142215-... | lld:pubmed |
| pubmed-article:3142215 | pubmed:meshHeading | pubmed-meshheading:3142215-... | lld:pubmed |
| pubmed-article:3142215 | pubmed:articleTitle | A large component of the antiviral activity of mouse interferon-gamma may be due to its induction of interferon-alpha. | lld:pubmed |
| pubmed-article:3142215 | pubmed:affiliation | Department of Microbiology, University of Texas Medical Branch, Galveston 77550. | lld:pubmed |
| pubmed-article:3142215 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3142215 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3142215 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3142215 | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3142215 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3142215 | lld:pubmed |
