| pubmed-article:3141501 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3141501 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:3141501 | lifeskim:mentions | umls-concept:C0206071 | lld:lifeskim |
| pubmed-article:3141501 | lifeskim:mentions | umls-concept:C1306673 | lld:lifeskim |
| pubmed-article:3141501 | lifeskim:mentions | umls-concept:C0037791 | lld:lifeskim |
| pubmed-article:3141501 | lifeskim:mentions | umls-concept:C1881379 | lld:lifeskim |
| pubmed-article:3141501 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:3141501 | pubmed:dateCreated | 1988-12-8 | lld:pubmed |
| pubmed-article:3141501 | pubmed:abstractText | The lineage and stage specificity of human isotype switch recombination was investigated by examining the IgH gene configuration in 61 hemopoietic malignancies representing different stages of B and T cell development. An unexpectedly high frequency (20%) of IgM-producing B cell leukemias and lymphomas had undergone CH gene rearrangements and deletions consistent with attempted switch recombination. These CH gene alterations were found on productive, non-productive, and 14q+ chromosomes. These data support the concept of a non-specific (common) switch recombinase activity that is often ineffective. No evidence of such switch recombination was found in 25 mu- or mu+ pre-B cell leukemias with the single exception of a mu- pre-B leukemia in which subsets of the cells were producing gamma- or alpha-H chains. The switch recombinase activity gamma- or alpha-H chains. The switch recombinase activity may be restricted to the B cell lineage, inasmuch as CH gene deletions were not observed in T lineage malignancies. | lld:pubmed |
| pubmed-article:3141501 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3141501 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3141501 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3141501 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3141501 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3141501 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:3141501 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3141501 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3141501 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3141501 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:3141501 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:3141501 | pubmed:author | pubmed-author:CooperM DMD | lld:pubmed |
| pubmed-article:3141501 | pubmed:author | pubmed-author:BurrowsP DPD | lld:pubmed |
| pubmed-article:3141501 | pubmed:author | pubmed-author:LandayAA | lld:pubmed |
| pubmed-article:3141501 | pubmed:author | pubmed-author:BorzilloG VGV | lld:pubmed |
| pubmed-article:3141501 | pubmed:author | pubmed-author:CastleberryRR | lld:pubmed |
| pubmed-article:3141501 | pubmed:author | pubmed-author:BertoliL FLF | lld:pubmed |
| pubmed-article:3141501 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3141501 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:3141501 | pubmed:volume | 141 | lld:pubmed |
| pubmed-article:3141501 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3141501 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3141501 | pubmed:pagination | 3625-33 | lld:pubmed |
| pubmed-article:3141501 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:3141501 | pubmed:meshHeading | pubmed-meshheading:3141501-... | lld:pubmed |
| pubmed-article:3141501 | pubmed:meshHeading | pubmed-meshheading:3141501-... | lld:pubmed |
| pubmed-article:3141501 | pubmed:meshHeading | pubmed-meshheading:3141501-... | lld:pubmed |
| pubmed-article:3141501 | pubmed:meshHeading | pubmed-meshheading:3141501-... | lld:pubmed |
| pubmed-article:3141501 | pubmed:meshHeading | pubmed-meshheading:3141501-... | lld:pubmed |
| pubmed-article:3141501 | pubmed:meshHeading | pubmed-meshheading:3141501-... | lld:pubmed |
| pubmed-article:3141501 | pubmed:meshHeading | pubmed-meshheading:3141501-... | lld:pubmed |
| pubmed-article:3141501 | pubmed:meshHeading | pubmed-meshheading:3141501-... | lld:pubmed |
| pubmed-article:3141501 | pubmed:meshHeading | pubmed-meshheading:3141501-... | lld:pubmed |
| pubmed-article:3141501 | pubmed:meshHeading | pubmed-meshheading:3141501-... | lld:pubmed |
| pubmed-article:3141501 | pubmed:meshHeading | pubmed-meshheading:3141501-... | lld:pubmed |
| pubmed-article:3141501 | pubmed:meshHeading | pubmed-meshheading:3141501-... | lld:pubmed |
| pubmed-article:3141501 | pubmed:meshHeading | pubmed-meshheading:3141501-... | lld:pubmed |
| pubmed-article:3141501 | pubmed:meshHeading | pubmed-meshheading:3141501-... | lld:pubmed |
| pubmed-article:3141501 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:3141501 | pubmed:articleTitle | Lineage and stage specificity of isotype switching in humans. | lld:pubmed |
| pubmed-article:3141501 | pubmed:affiliation | Department of Pediatrics, University of Alabama, Birmingham 35294. | lld:pubmed |
| pubmed-article:3141501 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3141501 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3141501 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
