| pubmed-article:3140862 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3140862 | lifeskim:mentions | umls-concept:C0235063 | lld:lifeskim |
| pubmed-article:3140862 | lifeskim:mentions | umls-concept:C0068377 | lld:lifeskim |
| pubmed-article:3140862 | lifeskim:mentions | umls-concept:C0680242 | lld:lifeskim |
| pubmed-article:3140862 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:3140862 | pubmed:dateCreated | 1988-12-8 | lld:pubmed |
| pubmed-article:3140862 | pubmed:abstractText | The duration of respiratory depression induced by morphine 10 mg/70 kg was studied following the administration of one of two opioid antagonists. Respiratory measurements included: (i) the ventilatory response to carbon dioxide, described in two ways--the minute ventilation at an end-tidal carbon dioxide partial pressure of 8 kPa (VE8) and the log slope of the ventilatory response to carbon dioxide; (ii) resting end-tidal carbon dioxide partial pressure; (iii) rate of ventilation. One hour after administration of morphine, one of the following was given i.v.: nalmefene 0.4 mg/70 kg; naloxone 0.4 mg/70 kg (low dose); naloxone 1.6 mg/70 kg (high dose); or saline placebo. The depression of VE8 by morphine was antagonized by all three treatments for the 1.5 h after the injection. However, for the 1.5-6 h after antagonist, VE8 following naloxone became depressed, whereas VE8 after nalmefene remained significantly increased compared with other treatments. Nalmefene restored the slope of the ventilatory response to baseline for 6 h and differed significantly from low but not high dose naloxone. Resting end-tidal carbon dioxide measurements demonstrated that nalmefene activity exceeded that of low but not high dose naloxone over the 1.5-4.5 h period. Rate of ventilation was not different between treatments. | lld:pubmed |
| pubmed-article:3140862 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3140862 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3140862 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3140862 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3140862 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3140862 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3140862 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3140862 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3140862 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3140862 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3140862 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:3140862 | pubmed:issn | 0007-0912 | lld:pubmed |
| pubmed-article:3140862 | pubmed:author | pubmed-author:JonesJ GJG | lld:pubmed |
| pubmed-article:3140862 | pubmed:author | pubmed-author:JordanCC | lld:pubmed |
| pubmed-article:3140862 | pubmed:author | pubmed-author:AltmanD GDG | lld:pubmed |
| pubmed-article:3140862 | pubmed:author | pubmed-author:KonieczkoK... | lld:pubmed |
| pubmed-article:3140862 | pubmed:author | pubmed-author:BarrowcliffeM... | lld:pubmed |
| pubmed-article:3140862 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3140862 | pubmed:volume | 61 | lld:pubmed |
| pubmed-article:3140862 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3140862 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3140862 | pubmed:pagination | 318-23 | lld:pubmed |
| pubmed-article:3140862 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:3140862 | pubmed:meshHeading | pubmed-meshheading:3140862-... | lld:pubmed |
| pubmed-article:3140862 | pubmed:meshHeading | pubmed-meshheading:3140862-... | lld:pubmed |
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| pubmed-article:3140862 | pubmed:meshHeading | pubmed-meshheading:3140862-... | lld:pubmed |
| pubmed-article:3140862 | pubmed:meshHeading | pubmed-meshheading:3140862-... | lld:pubmed |
| pubmed-article:3140862 | pubmed:meshHeading | pubmed-meshheading:3140862-... | lld:pubmed |
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| pubmed-article:3140862 | pubmed:meshHeading | pubmed-meshheading:3140862-... | lld:pubmed |
| pubmed-article:3140862 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:3140862 | pubmed:articleTitle | Antagonism of morphine-induced respiratory depression with nalmefene. | lld:pubmed |
| pubmed-article:3140862 | pubmed:affiliation | Division of Anaesthesia, Northwick Park Hospital, Harrow, Middx. | lld:pubmed |
| pubmed-article:3140862 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3140862 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:3140862 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:3140862 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3140862 | lld:pubmed |
